Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2621766 | 0.79 | CCNA2 (0.36) | PDE10AALDH1A1RAB9ATSHR | |
| SCHEMBL16654345 | 0.77 | FAAH (0.56) | ALDH1A1KDM4ERAB9AALOX5CYP1A2 | |
| SCHEMBL17958602 | 0.76 | PDE10A (0.49) | PDE10AMEN1MAPTKMT2AHTT | |
| SCHEMBL16654115 | 0.76 | PDE10A (0.49) | PDE10AMEN1MAPTKMT2AHTT | |
| SCHEMBL16653977 | 0.76 | PDE10A (0.49) | PDE10AMEN1MAPTKMT2AHTT | |
| SCHEMBL3097499 | 0.76 | FAAH (0.54) | ALDH1A1KDM4ERAB9AALOX5CYP1A2 | |
| SCHEMBL12066225 | 0.73 | PDE10A (1.00) | PDE10AMEN1MAPTKMT2A | |
| SCHEMBL22606727 | 0.71 | FFAR4 (0.41) | ALDH1A1RAB9ATSHR | |
| SCHEMBL3129644 | 0.71 | KDM4C (0.49) | ALDH1A1NPSR1KDM4EHSD17B10RAB9A | |
| SCHEMBL6851771 | 0.71 | PDE10A (0.77) | PDE10AMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057957-A1 | CYCLOPENTYLBENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PSYCHOTIC AND COGNITIVE DISORDERS | Takeda Pharmaceutical Company Limited (JP) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015055994-A1 | CYCLOPENTYLBENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PSYCHOTIC AND COGNITIVE DISORDERS | TAKEDA CAMBRIDGE LIMITED (GB) | 2015-04-23 | — | — | WO | disclosed |