Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MGMT | P16455 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14228268 | 0.80 | MGMT (0.48) | POLBMGMTLMNAGAAL3MBTL1 | |
| SCHEMBL9007594 | 0.77 | MGMT (0.50) | POLBMGMTLMNAGAAL3MBTL1 | |
| SCHEMBL12253970 | 0.75 | PTPN1 (0.47) | MGMTL3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL25037399 | 0.74 | PIN1 (0.45) | POLBMGMTLMNAGAAMEN1 | |
| SCHEMBL14199920 | 0.74 | GLRA1 (0.46) | POLBMGMTLMNAGAAMEN1 | |
| SCHEMBL7793968 | 0.72 | MEN1 (0.47) | POLBMGMTMEN1KMT2AMAPT | |
| SCHEMBL31440585 | 0.72 | MAPT (0.53) | LMNAMEN1KMT2AMAPTCYP19A1 | |
| SCHEMBL8903443 | 0.72 | MAPT (0.49) | MGMTNSD2ABL1PPARGRIN1 | |
| SCHEMBL12253971 | 0.71 | ALDH1A1 (0.46) | POLBL3MBTL1KMT2AMAPTALDH1A1 | |
| SCHEMBL647866 | 0.71 | TDP1 (0.56) | MGMTL3MBTL1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057586-A1 | BROMODOMAIN INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015058160-A1 | BROMODOMAIN INHIBITORS | Quanticel Pharmaceuticals, Inc. (US) | 2015-04-23 | — | — | WO | disclosed |