Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Stearic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 6/20 | 0.42 |
| ▸ | PPARG | P37231 | 6/20 | 0.42 |
| ▸ | PPARD | Q03181 | 6/20 | 0.42 |
| ▸ | PPARA | Q07869 | 6/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | TLR2 | O60603 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | FABP4 | P15090 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Atrazine SCHEMBL6047102 | 0.81 | GAA (0.49) | KMT2ALMNASMN1; SMN2ALDH1A1TSHR | |
| Terbuthylazine SCHEMBL9715292 | 0.81 | KMT2A (0.74) | KMT2ALMNASMN1; SMN2ALDH1A1PDE4A | |
| Terbuthylazine SCHEMBL8539245 | 0.81 | KMT2A (0.74) | KMT2ALMNASMN1; SMN2ALDH1A1PDE4A | |
| Terbuthylazine SCHEMBL9586446 | 0.78 | KMT2A (0.62) | KMT2ALMNASMN1; SMN2ALDH1A1PDE4A | |
| Terbuthylazine SCHEMBL19462952 | 0.77 | KMT2A (0.51) | KMT2ALMNASMN1; SMN2ALDH1A1PDE4A | |
| SCHEMBL3138830 | 0.73 | GPR84 (0.59) | KMT2AALDH1A1PDE4AGPR84PPARG | |
| SCHEMBL11786537 | 0.72 | KMT2A (0.76) | KMT2ALMNAPDE4ACYP1A2CYP2C19 | |
| SCHEMBL134610 | 0.72 | LMNA (0.68) | KMT2ALMNAALDH1A1PDE4ACYP1A2 | |
| Terbuthylazine SCHEMBL19463732 | 0.72 | GAA (0.72) | KMT2ALMNASMN1; SMN2ALDH1A1PDE4A | |
| Terbutryne SCHEMBL16594385 | 0.72 | KMT2A (0.60) | KMT2ALMNASMN1; SMN2ALDH1A1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2482802-A1 | NOVEL PESTICIDE FORMULATIONS | Burnet, Michael (DE) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011040956-A1 | NOVEL PESTICIDE FORMULATIONS | BURNET MICHAEL (DE) | 2011-04-07 | — | — | WO | disclosed |