Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16655484 | 0.87 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL7675491 | 0.84 | TSHR (0.50) | SMN1; SMN2KMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL18812998 | 0.80 | KMT2A (0.49) | SMN1; SMN2KMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL4592985 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2KMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL27528805 | 0.78 | ALDH1A1 (0.56) | SMN1; SMN2KMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL9359702 | 0.75 | MEN1 (0.46) | SMN1; SMN2KMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL9359710 | 0.75 | MEN1 (0.46) | SMN1; SMN2KMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL27879907 | 0.74 | KMT2A (0.48) | SMN1; SMN2KMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL8380441 | 0.74 | HPGD (0.49) | SMN1; SMN2KMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL4739425 | 0.74 | KMT2A (0.50) | SMN1; SMN2KMT2AMEN1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057943-A1 | PYRIMIDINE FGFR4 INHIBITORS | Eisai R&D Management Co., Ltd. (JP) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015057963-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |
| WO-2015057938-A1 | PYRIMIDINE FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |