Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORD | Q00796 | 9/20 | 0.41 |
| ▸ | IDO1 | P14902 | 3/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | LDLR | P01130 | 1/20 | 0.35 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17601377 | 0.80 | IDO1 (0.44) | IDO1PDPK1HPGDSIDH1KCNH2 | |
| SCHEMBL16462472 | 0.76 | RECQL (0.41) | IDO1HPGDSIDH1KCNH2LDLR | |
| SCHEMBL25136220 | 0.75 | KMO (0.47) | HPGDS | |
| SCHEMBL30182805 | 0.75 | KMO (0.47) | HPGDS | |
| Hydrochloric Acid SCHEMBL30182745 | 0.74 | KMO (0.46) | HPGDS | |
| SCHEMBL29182238 | 0.74 | HTR1A (0.41) | IDO1PDPK1HPGDSIDH1KCNH2 | |
| SCHEMBL30834332 | 0.74 | HTR1A (0.41) | IDO1PDPK1HPGDSIDH1KCNH2 | |
| Hydrochloric Acid SCHEMBL29182185 | 0.74 | KMO (0.46) | HPGDS | |
| SCHEMBL30182538 | 0.72 | MMP2 (0.50) | IDO1CYP1A2 | |
| SCHEMBL25136427 | 0.72 | MMP2 (0.50) | IDO1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057951-A1 | METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | Janssen Pharmaceutica N.V. (BE) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015057205-A1 | METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2015-04-23 | — | — | WO | disclosed |