Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | SLC18A3 | Q16572 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 3/20 | 0.46 |
| ▸ | HRH1 | P35367 | 3/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.45 |
| ▸ | RELA | Q04206 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4726771 | 0.86 | KCNH2 (0.60) | LMNAMEN1KMT2ACYP2C19HRH2 | |
| SCHEMBL8600930 | 0.81 | SMN1; SMN2 (0.64) | GAALMNASLC18A3MEN1KMT2A | |
| SCHEMBL18228641 | 0.80 | GAA (0.58) | GAASLC18A3MEN1ALDH1A1KMT2A | |
| SCHEMBL408202 | 0.79 | GPR119 (0.63) | GAASLC18A3HPGDKMT2APKM | |
| SCHEMBL29764409 | 0.79 | HRH2 (0.55) | GAALMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL21381855 | 0.79 | CYP2C19 (0.60) | GAALMNAALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL18228260 | 0.78 | SLC18A3 (0.57) | GAASLC18A3POLBSMN1; SMN2 | |
| SCHEMBL15646467 | 0.77 | SLC18A3 (0.58) | GAASLC18A3MEN1ALDH1A1KMT2A | |
| SCHEMBL13391294 | 0.76 | GPR119 (0.59) | GAASLC18A3HPGDKMT2APKM | |
| SCHEMBL15648095 | 0.76 | LMNA (0.43) | GAALMNAMAPTMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057950-A1 | PHENYL LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | Janssen Pharmaceutica N.V. (BE) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015057203-A1 | PHENYL LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2015-04-23 | — | — | WO | disclosed |