Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2848087 | 0.88 | SMN1; SMN2 (0.77) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2D6 | |
| SCHEMBL16655868 | 0.81 | L3MBTL1 (0.57) | SMN1; SMN2NPC1CYP2C9CYP2C19KMT2A | |
| SCHEMBL15646467 | 0.80 | SLC18A3 (0.58) | KMT2AGAASLC18A3MEN1 | |
| SCHEMBL9256664 | 0.80 | SMN1; SMN2 (0.68) | SMN1; SMN2NPC1RAB9ACYP2D6CYP2C9 | |
| SCHEMBL4063564 | 0.80 | SMN1; SMN2 (0.68) | SMN1; SMN2NPC1RAB9ACYP2C19KMT2A | |
| SCHEMBL14335634 | 0.80 | SMN1; SMN2 (0.68) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2D6 | |
| SCHEMBL205216 | 0.79 | SMN1; SMN2 (1.00) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2D6 | |
| SCHEMBL408202 | 0.78 | GPR119 (0.63) | KMT2AGAASLC18A3GPR119 | |
| Hydrochloric Acid SCHEMBL3097843 | 0.78 | SMN1; SMN2 (0.97) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2D6 | |
| SCHEMBL26538149 | 0.78 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719166-A | TREATING PSYCHOSES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1998-02-17 | — | — | US | disclosed |
| EP-0532177-B1 | Methanoanthracenes as dopamine antagonists | ZENECA LTD (GB) | 1996-10-16 | — | — | EP | disclosed |
| US-5550136-A | ANTAGONISTS OF DOPAMINE D-2 RECEPTORS | ZENECA LIMITED (GB) | 1996-08-27 | — | — | US | disclosed |
| US-5399568-A | Dopamine antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-03-21 | — | — | US | disclosed |
| EP-0532177-A1 | Methanoanthracenes as dopamine antagonists | ZENECA LIMITED (GB) | 1993-03-17 | — | — | EP | disclosed |