Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KHK | P50053 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16656002 | 0.90 | SIGMAR1 (0.55) | SIGMAR1POLBUSP2ALDH1A1TSHR | |
| SCHEMBL18921779 | 0.82 | SIGMAR1 (0.57) | SIGMAR1POLBUSP2ALDH1A1TSHR | |
| SCHEMBL18921784 | 0.82 | SIGMAR1 (0.57) | SIGMAR1POLBUSP2ALDH1A1TSHR | |
| SCHEMBL16655743 | 0.76 | SIGMAR1 (0.53) | SIGMAR1POLBUSP2ALDH1A1TSHR | |
| SCHEMBL7837595 | 0.75 | SIGMAR1 (0.68) | SIGMAR1POLBUSP2ALDH1A1TSHR | |
| SCHEMBL14677020 | 0.74 | TSHR (0.50) | POLBALDH1A1TSHRHSD17B10PARP1 | |
| SCHEMBL14677026 | 0.74 | TSHR (0.50) | POLBALDH1A1TSHRHSD17B10PARP1 | |
| SCHEMBL27784860 | 0.73 | SIGMAR1 (0.60) | SIGMAR1POLBUSP2ALDH1A1TSHR | |
| SCHEMBL27763342 | 0.72 | SIGMAR1 (0.55) | SIGMAR1POLBUSP2ALDH1A1TSHR | |
| SCHEMBL937374 | 0.72 | TSHR (0.48) | POLBALDH1A1TSHRHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015057963-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |