Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.55 |
| ▸ | VHL | P40337 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4204403 | 0.76 | EPHX2 (0.57) | EPHX2VHLPOLBUSP2NPC1 | |
| SCHEMBL4664040 | 0.75 | POLB (0.56) | EPHX2VHLPOLBUSP2NPC1 | |
| SCHEMBL21023373 | 0.71 | LMNA (0.59) | EPHX2VHLPOLBUSP2NPC1 | |
| SCHEMBL8235172 | 0.70 | EPHX2 (0.49) | EPHX2VHLPOLBUSP2NPC1 | |
| SCHEMBL6409949 | 0.69 | EPHX2 (0.57) | EPHX2POLBNPC1RAB9AKMT2A | |
| SCHEMBL6403162 | 0.68 | POLB (0.54) | EPHX2POLBUSP2NPC1RAB9A | |
| SCHEMBL4809579 | 0.67 | CYP2D6 (0.34) | — | |
| SCHEMBL1136794 | 0.65 | VHL (0.59) | EPHX2VHLPOLBUSP2KMT2A | |
| SCHEMBL81734 | 0.65 | — | — | |
| SCHEMBL17824733 | 0.64 | ALDH1A1 (0.56) | EPHX2POLBUSP2PDE10AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057943-A1 | PYRIMIDINE FGFR4 INHIBITORS | Eisai R&D Management Co., Ltd. (JP) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015057938-A1 | PYRIMIDINE FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |