Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | FASN | P49327 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16632006 | 0.89 | KDM4E (0.49) | KDM4EFASNMAPTMEN1KMT2A | |
| SCHEMBL16656115 | 0.81 | KDM4E (0.46) | KDM4EFASNMAPTMEN1KMT2A | |
| SCHEMBL15648185 | 0.78 | KDM4E (0.70) | KDM4EFASNMAPTMEN1KMT2A | |
| SCHEMBL15647838 | 0.78 | KDM4E (0.66) | KDM4EFASNMAPTMEN1KMT2A | |
| SCHEMBL4458154 | 0.70 | KDM4E (0.65) | KDM4EFASNMAPT | |
| SCHEMBL16652131 | 0.69 | ALDH1A1 (0.43) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL8783594 | 0.68 | MAPT (0.68) | KDM4EFASNMAPTMEN1KMT2A | |
| SCHEMBL16460645 | 0.68 | PTGES (0.58) | KDM4EFASNMAPTMEN1KMT2A | |
| SCHEMBL16651582 | 0.66 | GSK3B (0.40) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL8783601 | 0.66 | KDM4E (0.67) | KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057950-A1 | PHENYL LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | Janssen Pharmaceutica N.V. (BE) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015057203-A1 | PHENYL LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2015-04-23 | — | — | WO | disclosed |