Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 18/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | FABP3 | P05413 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16632084 | 0.78 | RORC (0.56) | RORC | |
| SCHEMBL15647202 | 0.75 | RORC (0.55) | RORCALDH1A1FABP3FABP4 | |
| SCHEMBL15647176 | 0.75 | RORC (0.48) | RORCALDH1A1RAB9ASMN1; SMN2FABP3 | |
| SCHEMBL16633049 | 0.74 | RORC (0.56) | RORC | |
| SCHEMBL16655904 | 0.71 | RORC (0.66) | RORC | |
| SCHEMBL15201636 | 0.70 | TAS1R3 (0.40) | ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL15646319 | 0.70 | NAPRT (0.50) | ALDH1A1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL22726319 | 0.69 | RORC (0.56) | RORC | |
| SCHEMBL16653816 | 0.69 | RAB9A (0.46) | HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL18754799 | 0.69 | RORC (0.45) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057421-A1 | ALKYL LINKED QUINOLINYL MODULATORS OF ROR(GAMMA)T | Janssen Pharmaceutica, N.V. (BE) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015057629-A1 | ALKYL LINKED QUINOLINYL MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2015-04-23 | — | — | WO | disclosed |