Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.46 |
| ▸ | FBP1 | P09467 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | IDH1 | O75874 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2790536 | 0.79 | ABL1 (0.48) | NPC1RAB9AMAPTCSNK1DFBP1 | |
| SCHEMBL4866482 | 0.71 | CSNK1D (0.52) | RAB9AMAPTCSNK1DFBP1POLB | |
| SCHEMBL4927460 | 0.70 | HDAC3 (0.67) | POLBTP53SMN1; SMN2MEN1KMT2A | |
| SCHEMBL15450923 | 0.69 | PIK3CA (0.51) | NPC1RAB9AMAPTFBP1POLB | |
| SCHEMBL17469473 | 0.68 | S1PR3 (0.60) | RAB9AMAPTFBP1 | |
| SCHEMBL23933083 | 0.68 | S1PR3 (0.54) | RAB9AMAPTCSNK1DFBP1 | |
| SCHEMBL2544240 | 0.68 | MAPT (0.48) | NPC1RAB9AMAPTCSNK1DFBP1 | |
| SCHEMBL26758738 | 0.68 | RAB9A (0.66) | NPC1RAB9ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2730689 | 0.68 | SMN1; SMN2 (0.85) | NPC1RAB9AMAPTTP53SMN1; SMN2 | |
| SCHEMBL30944307 | 0.68 | P2RX7 (0.44) | NPC1RAB9AMAPTCSNK1DFBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9012481-B2 | Benzoarylureido compounds, and composition for prevention or treatment of neurodegenerative brain disease containing the same | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2015-04-21 | — | — | US | disclosed |