SCHEMBL1665807

SCHEMBL1665807

CCSc1cnccc1-c1nc2cc(C(F)(F)F)ccc2s1

nearest known ligand 0.50

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ILK Q13418 2/20 0.50
AGPAT2 O15120 3/20 0.42
DYRK1A Q13627 9/20 0.40
ALOX5 P09917 1/20 0.39
PDE2A O00408 1/20 0.35
PDE7A Q13946 1/20 0.35
PDE10A Q9Y233 1/20 0.35
LMNA P02545 1/20 0.35
MAPT P10636 1/20 0.35
AKR1B1 P15121 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1666257 0.87 ILK (0.53) ILKAGPAT2DYRK1AALOX5PDE2A
SCHEMBL9952774 0.85 ILK (0.50) ILKAGPAT2DYRK1AALOX5LMNA
SCHEMBL11953193 0.84 MAPT (0.47) DYRK1ALMNAMAPT
SCHEMBL11895332 0.83 POLB (0.33) ILKPDE2APDE7APDE10A
SCHEMBL1665863 0.80 ILK (0.57) ILKAGPAT2DYRK1APDE2APDE7A
SCHEMBL11894802 0.79 ILK (0.49) ILKAGPAT2DYRK1AALOX5
SCHEMBL1666264 0.79 ILK (0.56) ILKAGPAT2DYRK1APDE2APDE7A
SCHEMBL11894585 0.78 ILK (0.48) ILKAGPAT2DYRK1AALOX5PDE2A
SCHEMBL1665870 0.78 ILK (0.53) ILKAGPAT2DYRK1AMAPT
SCHEMBL17309729 0.78 ILK (0.45) ILKAGPAT2DYRK1AALOX5LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2486035-B1 HETEROCYCLIC COMPOUND AND ITS USE FOR CONTROL OF AN ARTHROPOD PEST SUMITOMO CHEMICAL CO (JP) 2015-08-26 EP disclosed
EP-2486035-B1 HETEROCYCLIC COMPOUND AND ITS USE FOR CONTROL OF AN ARTHROPOD PEST SUMITOMO CHEMICAL CO (JP) 2015-08-26 EP disclosed
US-8742112-B2 Heterocyclic compound and its use for control of an arthropod pest SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-06-03 US disclosed
US-8742112-B2 Heterocyclic compound and its use for control of an arthropod pest SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-06-03 US disclosed
EP-2486035-A1 HETEROCYCLIC COMPOUND AND ITS USE FOR CONTROL OF AN ARTHROPOD PEST Sumitomo Chemical Co., Ltd (JP) 2012-08-15 EP disclosed
US-20120196891-A1 HETEROCYCLIC COMPOUND AND ITS USE FOR CONTROL OF AN ARTHROPOD PEST SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-08-02 US disclosed
US-20120196891-A1 HETEROCYCLIC COMPOUND AND ITS USE FOR CONTROL OF AN ARTHROPOD PEST SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-08-02 US disclosed
WO-2011043404-A1 HETEROCYCLIC COMPOUND AND ITS USE FOR CONTROL OF AN ARTHROPOD PEST SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-04-14 WO disclosed
WO-2011043404-A1 HETEROCYCLIC COMPOUND AND ITS USE FOR CONTROL OF AN ARTHROPOD PEST SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-04-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120196891-A1 HETEROCYCLIC COMPOUND AND ITS USE FOR CONTROL OF AN ARTHROPOD PEST HAAO, DDT, ACHE ILK 4502/4885AGPAT2 1107/4885DYRK1A 4590/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.