SCHEMBL1666264

SCHEMBL1666264

FC(F)(F)c1ccc2sc(-c3ccncc3Cl)nc2c1

nearest known ligand 0.56

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ILK Q13418 2/20 0.56
AGPAT2 O15120 3/20 0.52
DYRK1A Q13627 7/20 0.44
KIF11 P52732 2/20 0.38
LATS1 O95835 1/20 0.37
EPHX2 P34913 1/20 0.37
SCN4A P35499 1/20 0.37
PDE2A O00408 1/20 0.37
PDE7A Q13946 1/20 0.37
PDE10A Q9Y233 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1666275 0.90 EPHX2 (0.49) ILKAGPAT2DYRK1AKIF11EPHX2
SCHEMBL1665863 0.86 ILK (0.57) ILKAGPAT2DYRK1ALATS1EPHX2
SCHEMBL1665437 0.84 ILK (0.53) ILKAGPAT2DYRK1A
SCHEMBL1665870 0.81 ILK (0.53) ILKAGPAT2DYRK1A
SCHEMBL1666257 0.81 ILK (0.53) ILKAGPAT2DYRK1APDE2APDE7A
SCHEMBL11895093 0.81 RAB9A (0.39) ILKAGPAT2DYRK1ALATS1PDE2A
SCHEMBL11953190 0.80 DYRK1A (0.49) AGPAT2DYRK1ALATS1
SCHEMBL27557191 0.80 ILK (0.59) ILKAGPAT2DYRK1AEPHX2SCN4A
SCHEMBL1665807 0.79 ILK (0.50) ILKAGPAT2DYRK1APDE2APDE7A
SCHEMBL8704110 0.78 KDM4E (0.55) ILKAGPAT2DYRK1AKIF11EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2486035-B1 HETEROCYCLIC COMPOUND AND ITS USE FOR CONTROL OF AN ARTHROPOD PEST SUMITOMO CHEMICAL CO (JP) 2015-08-26 EP disclosed
EP-2486035-B1 HETEROCYCLIC COMPOUND AND ITS USE FOR CONTROL OF AN ARTHROPOD PEST SUMITOMO CHEMICAL CO (JP) 2015-08-26 EP disclosed
CN-102686585-B Heterocyclic compound and its use for control of an arthropod pest SUMITOMO CHEMICAL CO.,LTD. (JP) 2014-10-08 CN disclosed
US-8742112-B2 Heterocyclic compound and its use for control of an arthropod pest SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-06-03 US disclosed
US-8742112-B2 Heterocyclic compound and its use for control of an arthropod pest SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-06-03 US disclosed
CN-102686585-A Heterocyclic compound and its use for control of an arthropod pest SUMITOMO CHEMICAL CO 2012-09-19 CN disclosed
EP-2486035-A1 HETEROCYCLIC COMPOUND AND ITS USE FOR CONTROL OF AN ARTHROPOD PEST Sumitomo Chemical Co., Ltd (JP) 2012-08-15 EP disclosed
US-20120196891-A1 HETEROCYCLIC COMPOUND AND ITS USE FOR CONTROL OF AN ARTHROPOD PEST SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-08-02 US disclosed
US-20120196891-A1 HETEROCYCLIC COMPOUND AND ITS USE FOR CONTROL OF AN ARTHROPOD PEST SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-08-02 US disclosed
WO-2011043404-A1 HETEROCYCLIC COMPOUND AND ITS USE FOR CONTROL OF AN ARTHROPOD PEST SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-04-14 WO disclosed
WO-2011043404-A1 HETEROCYCLIC COMPOUND AND ITS USE FOR CONTROL OF AN ARTHROPOD PEST SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-04-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120196891-A1 HETEROCYCLIC COMPOUND AND ITS USE FOR CONTROL OF AN ARTHROPOD PEST HAAO, DDT, ACHE ILK 4502/4885AGPAT2 1107/4885DYRK1A 4590/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.