Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.41 |
| ▸ | JAK1 | P23458 | 15/20 | 0.41 |
| ▸ | JAK3 | P52333 | 14/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665973 | 0.97 | MEN1 (0.40) | JAK2JAK1JAK3TNIKHDAC1 | |
| SCHEMBL1665019 | 0.88 | TNIK (0.41) | TNIKALDH1A1MAPTHPGDNPSR1 | |
| SCHEMBL8775930 | 0.86 | PIN1 (0.42) | TNIKALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL1666719 | 0.85 | MAPT (0.39) | TNIKMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL1665021 | 0.84 | ALDH1A1 (0.41) | TNIKALDH1A1MAPTHPGDNPSR1 | |
| SCHEMBL1664054 | 0.84 | TNIK (0.42) | TNIKMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL6126370 | 0.82 | DHODH (0.39) | TNIKALDH1A1MAPTKMT2A | |
| SCHEMBL1666717 | 0.82 | KDM4E (0.39) | MAPT | |
| SCHEMBL1664697 | 0.81 | MAPT (0.41) | TNIKMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL1664050 | 0.80 | DHODH (0.42) | JAK2TNIKALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |