SCHEMBL1666017

SCHEMBL1666017

C1=NC=C2C=NCN2c2ccccc21

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL886893 0.73 SIGMAR1 (0.36)
SCHEMBL30843927 0.73 SIGMAR1 (0.36)
SCHEMBL1651422 0.71
Hydrochloric Acid SCHEMBL2340700 0.70
SCHEMBL31441279 0.66 CYP11B2 (0.42)
SCHEMBL3689993 0.66 P2RX7 (0.33)
SCHEMBL18839284 0.66
SCHEMBL2461275 0.65 P2RX4 (0.34)
SCHEMBL3336306 0.65 SCN9A (0.39)
SCHEMBL2263869 0.64 KDM4E (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888354-A1 PROCESS FOR PRODUCING RADIOLABELLED BENZODIAZEPINE RECEPTOR AGENTS AND COMPOSITION CONTAINING THE SAME Map Medical Technologies Oy (FI) 1999-01-07 EP claimed
WO-1997034898-A1 PROCESS FOR PRODUCING RADIOLABELLED BENZODIAZEPINE RECEPTOR AGENTS AND COMPOSITION CONTAINING THE SAME MAP MEDICAL TECHNOLOGIES OY (FI) 1997-09-25 WO claimed
US-12083126-B2 Pharmaceutical compositions and methods for anesthesiological applications MELT PHARMACEUTICALS, INC. (US) 2024-09-10 US disclosed
EP-4399211-A1 IMIDAZOBENZODIAZEPINES FOR TREATMENT OF COGNITIVE AND MOOD SYMPTOMS UWM Research Foundation, Inc. (US) 2024-07-17 EP disclosed
WO-2023039018-A1 IMIDAZOBENZODIAZEPINES FOR TREATMENT OF COGNITIVE AND MOOD SYMPTOMS UWM RESEARCH FOUNDATION, INC. (US) 2023-03-16 WO disclosed
US-20220249510-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR ANESTHESIOLOGICAL APPLICATIONS FIFTH THIRD BANK, NATIONAL ASSOCIATION, AS AGENT 2022-08-11 US disclosed
US-20210085691-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR ANESTHESIOLOGICAL APPLICATIONS FIFTH THIRD BANK, NATIONAL ASSOCIATION, AS AGENT 2021-03-25 US disclosed
US-20200297734-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR ANESTHESIOLOGICAL APPLICATIONS FIFTH THIRD BANK, NATIONAL ASSOCIATION, AS AGENT 2020-09-24 US disclosed
US-10682310-B2 Therapeutic compounds and formulations for intranasal delivery REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2020-06-16 US disclosed
US-10391102-B2 Pharmaceutical compositions and methods for anesthesiological applications MELT PHARMACEUTICALS, INC. (US) 2019-08-27 US disclosed
US-20190142841-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR ANESTHESIOLOGICAL APPLICATIONS HARROW IP, LLC 2019-05-16 US disclosed
WO-2011042550-A1 [18 F] - LABELLED ANALOGUES OF FLUMAZENIL AS IN VIVO IMAGING AGENTS GE HEALTHCARE LIMITED (GB) 2011-04-14 WO disclosed
US-20100261711-A1 SELECTIVE ANTICONVULSANT AGENTS AND THEIR USES WISYS TECHNOLOGY FOUNDATION (US) 2010-10-14 US disclosed
EP-0100906-B1 TRI- AND TETRACYCLIC IMIDAZO(1,5-A)(1,4)BENZODIAZEPIN-1-CARBOXYLIC-ACID DERIVATIVES F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1987-05-13 EP disclosed
EP-0100906-A2 Tri- and tetracyclic imidazo(1,5-a)(1,4)benzodiazepin-1-carboxylic-acid derivatives F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1984-02-22 EP disclosed
US-4386028-A ANTIDOTES FOR OVERDOSES OF BENZODIAZEPINE TRANQUILIZERS HOFFMANN-LA ROCHE INC. (US) 1983-05-31 US disclosed
US-4377523-A Imidazodiazepines and processes therefor HOFFMANN-LA ROCHE INC. (US) 1983-03-22 US disclosed
US-4371468-A ANTICONVULSANTS, MUSCLE RELAXANTS, AND SEDATIVES HOFFMANN-LA ROCHE INC. (US) 1983-02-01 US disclosed
US-4146722-A SEDATIVES, MUSCLE RELAXANTS, ANTICONVULSANTS HOFFMANN-LA ROCHE INC. (US) 1979-03-27 US disclosed
US-4125726-A SEDATIVES, MUSCLE RELAXANTS, ANXIOLYTICS, ANTICONVULSANTS HOFFMANN-LA ROCHE INC. (US) 1978-11-14 US disclosed