Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | JMJD7 | P0C870 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | STAT1 | P42224 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16664917 | 0.84 | CYP1A2 (0.44) | KDM4EALDH1A1RAB9ANPC1HPGD | |
| SCHEMBL15343107 | 0.80 | HDAC1 (0.53) | KDM4EALDH1A1RAB9ANPC1HPGD | |
| SCHEMBL16664982 | 0.78 | CYP1A2 (0.49) | KDM4EALDH1A1HPGDLCKMAPK14 | |
| SCHEMBL15356474 | 0.72 | HCAR3 (0.45) | KDM4EALDH1A1RAB9ANPC1GAA | |
| SCHEMBL15356563 | 0.71 | CLK4 (0.39) | ALDH1A1LMNAKMT2ASMN1; SMN2MAPK14 | |
| SCHEMBL19905203 | 0.71 | SLC40A1 (0.38) | KDM4EALDH1A1RAB9ANPC1HPGD | |
| SCHEMBL17634777 | 0.71 | PRKDC (0.45) | KDM4EALDH1A1RAB9ANPC1HPGD | |
| SCHEMBL19905206 | 0.70 | CYP1A2 (0.37) | KDM4EALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL15342936 | 0.70 | PTGDR (0.45) | ALDH1A1HPGDLMNAKMT2ACYP1A2 | |
| SCHEMBL15343417 | 0.70 | PIK3CA (0.40) | HPGDLMNAMAPK14TSHRPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150111871-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150111871-A1 | DNA-PK INHIBITORS | POLK, DTYMK, DCK | KDM4E 910/4885ALDH1A1 2935/4885RAB9A 4213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.