Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 8/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.45 |
| ▸ | TSHR | P16473 | 9/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 9/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15473058 | 0.86 | FAAH (0.49) | FAAHHRH4CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16664967 | 0.84 | CYP1A2 (0.45) | FAAHCYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL12764505 | 0.81 | HRH4 (0.47) | FAAHHRH4TSHRCYP2C19TP53 | |
| SCHEMBL15356483 | 0.79 | HRH4 (0.47) | FAAHHRH4PIK3CA | |
| SCHEMBL16664984 | 0.78 | FAAH (0.46) | FAAHHRH4CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL15343308 | 0.74 | AAK1 (0.50) | FAAHHRH4CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL15343419 | 0.74 | FAAH (0.50) | FAAHHRH4PIK3CA | |
| SCHEMBL17700604 | 0.74 | LOX (0.45) | HRH4CYP3A4 | |
| SCHEMBL16664939 | 0.74 | CLK4 (0.42) | FAAHCYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL15343067 | 0.73 | AURKA (0.46) | FAAHHRH4CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150111871-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150111871-A1 | DNA-PK INHIBITORS | POLK, DTYMK, DCK | FAAH 3955/4885HRH4 2433/4885CYP1A2 2215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.