Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16660290 | 0.85 | DYRK1A (0.41) | ALDH1A1TSHRKMT2ASMN1; SMN2LMNA | |
| SCHEMBL10123046 | 0.83 | ALDH1A1 (0.49) | ALDH1A1CYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL10122991 | 0.83 | AURKA (0.49) | ALDH1A1CYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL14546516 | 0.82 | ALDH1A1 (0.49) | ALDH1A1CYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL10123002 | 0.77 | AURKA (0.48) | ALDH1A1TSHRLMNA | |
| SCHEMBL10122960 | 0.77 | AURKA (0.54) | ALDH1A1CYP1A2KMT2ASMN1; SMN2LMNA | |
| SCHEMBL10123014 | 0.72 | AURKA (0.49) | ALDH1A1CYP2C9LMNAPOLBNPC1 | |
| SCHEMBL10122962 | 0.71 | AURKA (0.49) | CYP1A2CYP3A4CYP2C9TGFBR1 | |
| SCHEMBL10123026 | 0.70 | AURKA (0.47) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL13762804 | 0.70 | IGF1R (0.43) | ALDH1A1TSHRKMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928456-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MIIKANA THERAPEUTICS INC (US) | 2015-04-22 | — | — | EP | disclosed |