Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.59 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | QDPR | P09417 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR1E | P28566 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL724585 | 1.00 | HTR3A (0.59) | HTR3AKDM1AMAOBCYP2D6SLC6A2 | |
| SCHEMBL28298496 | 0.92 | HTR3A (0.51) | HTR3AKDM1AMAOBCYP2D6SLC6A2 | |
| SCHEMBL24127250 | 0.91 | CYP2D6 (0.54) | HTR3AKDM1AMAOBCYP2D6SLC6A2 | |
| SCHEMBL1765234 | 0.89 | QDPR (0.56) | HTR3AKDM1AMAOBSLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL1764764 | 0.87 | QDPR (0.55) | HTR3AKDM1AMAOBSLC6A2SLC6A4 | |
| SCHEMBL1825489 | 0.84 | HTR3A (0.64) | HTR3ACYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13698229 | 0.84 | HTR3A (0.54) | HTR3ACYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1823960 | 0.84 | SLC6A2 (0.59) | HTR3ACYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22608997 | 0.84 | QDPR (0.57) | HTR3ACYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27825252 | 0.84 | HTR3A (0.50) | HTR3AKDM1ACYP2D6SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681215-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-04-22 | — | — | EP | disclosed |