Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 6/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.59 |
| ▸ | HTR3A | P46098 | 2/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | HTR1D | P28221 | 1/20 | 0.52 |
| ▸ | HTR1B | P28222 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | HTR1E | P28566 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | HTR5A | P47898 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31342377 | 0.90 | QDPR (0.51) | SLC6A2SLC6A4CYP2D6SLC6A3KCNH2 | |
| SCHEMBL3383243 | 0.90 | QDPR (0.51) | SLC6A2SLC6A4CYP2D6SLC6A3KCNH2 | |
| Hydrochloric Acid SCHEMBL4778776 | 0.88 | QDPR (0.50) | SLC6A2SLC6A4CYP2D6SLC6A3KCNH2 | |
| SCHEMBL1825489 | 0.87 | HTR3A (0.64) | SLC6A2SLC6A4CYP2D6SLC6A3KCNH2 | |
| SCHEMBL13093036 | 0.84 | SLC6A2 (0.81) | SLC6A2SLC6A4CYP2D6SLC6A3KCNH2 | |
| SCHEMBL16660426 | 0.84 | HTR3A (0.59) | SLC6A2SLC6A4CYP2D6SLC6A3KCNH2 | |
| SCHEMBL1823096 | 0.84 | SLC6A2 (0.81) | SLC6A2SLC6A4CYP2D6SLC6A3KCNH2 | |
| SCHEMBL724585 | 0.84 | HTR3A (0.59) | SLC6A2SLC6A4CYP2D6SLC6A3KCNH2 | |
| Hydrochloric Acid SCHEMBL27410631 | 0.83 | SLC6A2 (0.78) | SLC6A2SLC6A4CYP2D6SLC6A3KCNH2 | |
| SCHEMBL15516731 | 0.80 | SLC6A3 (0.46) | SLC6A2SLC6A4CYP2D6SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155669-B1 | NEW DISUBSTITUTED PHENYLPYRROLIDINES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION | NSAB AF NEUROSEARCH SWEDEN AB (DK) | 2011-05-04 | — | — | EP | disclosed |
| US-20100197760-A1 | DISUBSTITUTED PHENYLPYRROLIDINES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2010-08-05 | — | — | US | disclosed |
| CN-101711234-A | New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission | NSAB OF NEUROSEARCH SWEDEN AB | 2010-05-19 | — | — | CN | disclosed |
| EP-2155669-A1 | NEW DISUBSTITUTED PHENYLPYRROLIDINES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION | NSAB, Filial af NeuroSearch Sweden AB, Sverige (DK) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008148799-A1 | NEW DISUBSTITUTED PHENYLPYRROLIDINES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION | NSAB, FILIAL OF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2008-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197760-A1 | DISUBSTITUTED PHENYLPYRROLIDINES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION | SLC6A2, SLC6A3, SLC18A2 | SLC6A2 1/4885SLC6A4 12/4885CYP2D6 655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.