Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | SLC13A5 | Q86YT5 | 12/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HMGCR | P04035 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL28787546 | 1.00 | ALDH1A1 (0.65) | ALDH1A1SLC13A5LMNAKDM4ECYP1A2 | |
| Citric Acid SCHEMBL1666464 | 1.00 | ALDH1A1 (0.65) | ALDH1A1SLC13A5LMNAKDM4ECYP1A2 | |
| Citric Acid SCHEMBL27903186 | 0.96 | ALDH1A1 (0.60) | ALDH1A1SLC13A5LMNAKDM4ECYP1A2 | |
| Citric Acid SCHEMBL27413422 | 0.89 | ALDH1A1 (0.62) | ALDH1A1SLC13A5LMNAKDM4ECYP1A2 | |
| Citric Acid SCHEMBL29150802 | 0.87 | ALDH1A1 (0.65) | ALDH1A1SLC13A5LMNAKDM4ECYP1A2 | |
| Citric Acid SCHEMBL1550236 | 0.86 | ALDH1A1 (0.88) | ALDH1A1SLC13A5LMNAKDM4ECYP1A2 | |
| Citric Acid SCHEMBL1350456 | 0.83 | ALDH1A1 (0.94) | ALDH1A1SLC13A5LMNAKDM4ECYP1A2 | |
| Citric Acid SCHEMBL9392300 | 0.81 | ALDH1A1 (0.88) | ALDH1A1SLC13A5LMNAKDM4ECYP1A2 | |
| Citric Acid SCHEMBL7995770 | 0.81 | ALDH1A1 (0.88) | ALDH1A1SLC13A5LMNAKDM4ECYP1A2 | |
| Citric Acid SCHEMBL20536693 | 0.81 | ALDH1A1 (0.88) | ALDH1A1SLC13A5LMNAKDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240124371-A1 | NITRIFICATION INHIBITORS AND FORMULATIONS | INCITEC FERTILISERS OPERATIONS PTY LTD (AU) | 2024-04-18 | — | — | US | claimed |
| EP-4175630-A1 | POLYCYCLIC AMINES FOR OPIOID RECEPTOR MODULATION | Ecstasy LLC (US) | 2023-05-10 | — | — | EP | claimed |
| WO-2022126195-A1 | IMPROVED NITRIFICATION INHIBITORS AND FORMULATIONS | Incitec Pivot Limited (AU) | 2022-06-23 | — | — | WO | claimed |
| CN-101693714-B | Spirocyclic cyclohexane derivatives | GRUENENTHAL GMBH | 2013-05-29 | — | — | CN | claimed |
| CN-102150670-A | Application of phenanthroindolizidine and phenanthroquinolizidine derivatives and salts thereof in pesticides | UNIV NANKAI | 2011-08-17 | — | — | CN | claimed |
| CN-101693714-A | spirocyclic cyclohexane derivatives | GRUENENTHAL CHEMIE | 2010-04-14 | — | — | CN | claimed |
| CN-100577664-C | Spirocyclic cyclohexane derivatives | GRUENENTHAL GMBH | 2010-01-06 | — | — | CN | claimed |
| CN-1735619-A | spirocyclic cyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2006-02-15 | — | — | CN | claimed |
| CN-1198605-C | Compound with 5-HT1A activity useful for treating disorders of outer retina | ALCON UNIVERSAL LTD (CH) | 2005-04-27 | — | — | CN | claimed |
| US-20240124371-A1 | NITRIFICATION INHIBITORS AND FORMULATIONS | INCITEC FERTILISERS OPERATIONS PTY LTD (AU) | 2024-04-18 | — | — | US | disclosed |
| CN-113056208-B | Aerosol formulation | 尼科创业贸易有限公司 | 2023-05-05 | — | — | CN | disclosed |
| EP-3873242-B1 | AEROSOLISABLE FORMULATION | NICOVENTURES TRADING LTD (GB) | 2023-01-11 | — | — | EP | disclosed |
| CN-114989135-A | Organic acid salt of 2-methyl-5- (1-methylpyrrolidine-2-yl) pyridine and preparation method thereof | 广州天然科技有限公司 | 2022-09-02 | — | — | CN | disclosed |
| WO-2022126195-A1 | IMPROVED NITRIFICATION INHIBITORS AND FORMULATIONS | Incitec Pivot Limited (AU) | 2022-06-23 | — | — | WO | disclosed |
| US-5238938-A | Nephrosis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-08-24 | — | — | US | disclosed |
| CN-1067053-A | Pyrazines derivatives and preparation method thereof | OTSUKA PHARMA CO LTD (JP) | 1992-12-16 | — | — | CN | disclosed |
| EP-0511879-A1 | Pyrazine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |
| CN-1049155-A | INDOLE DERIVATIVES | OTSUKA CHEMICAL CO LTD (JP) | 1991-02-13 | — | — | CN | disclosed |
| EP-0411150-A1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-06 | — | — | EP | disclosed |
| US-4238518-A | Process for the preparation of a stable Beta vulgaris extract | LABORATOIRE L. LAFON (FR) | 1980-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240124371-A1 | NITRIFICATION INHIBITORS AND FORMULATIONS | NOS1, NOS2, NAT1 | MEN1 2300/4885ALDH1A1 693/4885SLC13A5 363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.