Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16664724 | 1.00 | CYP11B1 (0.34) | CYP11B1CYP11B2NLRP3HPGDHSD17B10 | |
| SCHEMBL16653824 | 0.80 | RXRA (0.33) | HSD17B10 | |
| SCHEMBL16664711 | 0.75 | CYP11B1 (0.61) | CYP11B1CYP11B2 | |
| SCHEMBL16664713 | 0.75 | CYP11B1 (0.61) | CYP11B1CYP11B2 | |
| SCHEMBL6784162 | 0.74 | SMN1; SMN2 (0.44) | NLRP3HPGDHSD17B10MAPK1ESR2 | |
| SCHEMBL24662339 | 0.73 | CTDSP1 (0.43) | HPGDHSD17B10MAPK1ESR2CTDSP1 | |
| SCHEMBL10529551 | 0.71 | RXRA (0.41) | CYP11B1CYP11B2NLRP3MAPK1ESR2 | |
| SCHEMBL7916179 | 0.71 | RXRA (0.41) | CYP11B1CYP11B2NLRP3MAPK1ESR2 | |
| SCHEMBL10529557 | 0.71 | RXRA (0.41) | CYP11B1CYP11B2NLRP3MAPK1ESR2 | |
| SCHEMBL13441754 | 0.70 | CTDSP1 (0.54) | HPGDMAPK1CTDSP1TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057941-B1 | NEW PHENYL-DIHYDROPYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2019-11-20 | — | — | EP | disclosed |
| US-9636339-B2 | Phenyl-dihydropyridine derivatives as aldosterone synthase inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2017-05-02 | — | — | US | disclosed |
| US-9636339-B2 | Phenyl-dihydropyridine derivatives as aldosterone synthase inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2017-05-02 | — | — | US | disclosed |
| US-20160229807-A1 | NEW PHENYL-DIHYDROPYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2016-08-11 | — | — | US | disclosed |
| US-20160229807-A1 | NEW PHENYL-DIHYDROPYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2016-08-11 | — | — | US | disclosed |
| WO-2015055604-A1 | NEW PHENYL-DIHYDROPYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229807-A1 | NEW PHENYL-DIHYDROPYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | REN, CYP21A2, AGTR1 | CYP11B1 7/4885CYP11B2 15/4885NLRP3 1308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.