Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 6/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | DNM2 | P50570 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15356586 | 0.84 | FAAH (0.47) | FAAHPIK3CAHRH4PRKDC | |
| SCHEMBL16665002 | 0.82 | PIK3CA (0.45) | FAAHPIK3CACLK4HRH4CDC7 | |
| SCHEMBL16664979 | 0.80 | FAAH (0.39) | FAAHPIK3CAFLT3TYRO3MERTK | |
| SCHEMBL16664909 | 0.79 | CYP1A2 (0.43) | FAAHPIK3CAFLT3TYRO3MERTK | |
| SCHEMBL16664949 | 0.78 | FLT3 (0.39) | FAAHPIK3CAFLT3TYRO3MERTK | |
| SCHEMBL16664954 | 0.78 | FAAH (0.46) | FAAHPIK3CACLK4CYP1A2ALDH1A1 | |
| SCHEMBL18627034 | 0.78 | PIK3CA (0.43) | FAAHPIK3CACLK4HRH4CYP1A2 | |
| SCHEMBL16664919 | 0.76 | PIK3CA (0.44) | FAAHPIK3CAFLT3TYRO3MERTK | |
| SCHEMBL16664969 | 0.76 | KDM4E (0.47) | FAAHPIK3CACLK4CDC7ROCK2 | |
| SCHEMBL15343048 | 0.76 | KDM4E (0.47) | FAAHPIK3CACLK4CDC7ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015058031-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-04-23 | — | — | WO | disclosed |