Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPK3 | P27361 | 6/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16665218 | 0.89 | EGFR (0.46) | KDREGFRJAK3BTKHTR2C | |
| SCHEMBL16665213 | 0.84 | MAPK3 (0.42) | MAPK3KDRFGFR1FGFR4EGFR | |
| SCHEMBL16665205 | 0.82 | L3MBTL1 (0.51) | L3MBTL1MAPK3MAPK1MAP2K1KDR | |
| SCHEMBL16665217 | 0.80 | MAPK3 (0.48) | L3MBTL1MAPK3MAPK1MAP2K1FGFR1 | |
| SCHEMBL16665245 | 0.76 | FGFR4 (0.50) | MAPK3FGFR1FGFR4EGFR | |
| SCHEMBL16665367 | 0.74 | FGFR4 (0.49) | MAPK3MAPK1MAP2K1KDRPDGFRB | |
| SCHEMBL12185524 | 0.69 | KDR (0.39) | KDRKITFGFR1CYP3A4CYP2D6 | |
| SCHEMBL16655795 | 0.69 | L3MBTL1 (0.44) | L3MBTL1KDRFGFR1EGFRJAK3 | |
| SCHEMBL13169364 | 0.68 | MAPK3 (0.50) | MAPK3MAPK1MAP2K1FGFR4EGFR | |
| SCHEMBL16655392 | 0.67 | KDR (0.48) | KDRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015057963-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |