SCHEMBL16666232

SCHEMBL16666232

NC(=O)NCCOC(=O)C(Cc1cc(=O)[nH]c2ccccc12)NC(=O)c1ccc(Cl)cc1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
UBASH3B Q8TF42 1/20 0.69
TACR1 P25103 5/20 0.51
F11 P03951 3/20 0.49
KMT2A Q03164 3/20 0.46
MEN1 O00255 2/20 0.46
KDM4E B2RXH2 2/20 0.44
ALDH1A1 P00352 1/20 0.44
PKM P14618 1/20 0.44
LNPEP Q9UIQ6 1/20 0.43
CCKBR P32239 1/20 0.42
PPARG P37231 1/20 0.42
KLKB1 P03952 1/20 0.42
ATM Q13315 1/20 0.42
LMNA P02545 1/20 0.42
TP53 P04637 1/20 0.42
MAPT P10636 1/20 0.42
THRB P10828 1/20 0.42
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
SIRT1 Q96EB6 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16666789 0.92 UBASH3B (0.73) UBASH3BTACR1F11KMT2AMEN1
Oxalic Acid SCHEMBL16666402 0.90 UBASH3B (0.70) UBASH3BTACR1F11KMT2AMEN1
SCHEMBL16666780 0.89 UBASH3B (0.71) UBASH3BTACR1F11KMT2AMEN1
SCHEMBL16666606 0.88 UBASH3B (0.67) UBASH3BTACR1F11KMT2AMEN1
SCHEMBL16666831 0.88 UBASH3B (0.67) UBASH3BTACR1F11KMT2AMEN1
SCHEMBL16666431 0.88 UBASH3B (0.75) UBASH3BTACR1F11KMT2AMEN1
SCHEMBL16666247 0.87 UBASH3B (0.74) UBASH3BTACR1F11KMT2AMEN1
SCHEMBL16666451 0.87 UBASH3B (0.74) UBASH3BTACR1F11KMT2AMEN1
SCHEMBL16666706 0.87 UBASH3B (0.68) UBASH3BTACR1F11KMT2AMEN1
SCHEMBL16666561 0.86 UBASH3B (0.72) UBASH3BTACR1F11KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11420963-B2 Rebamipide prodrugs, preparation method and use thereof SAMJIN PHARMACEUTICAL CO., LTD. (KR) 2022-08-23 US claimed
EP-2865669-B1 NOVEL REBAMIPIDE PRODRUG, METHOD FOR PRODUCING SAME, AND USAGE THEREOF SAMJIN PHARM CO LTD (KR) 2021-04-28 EP claimed
US-20150141409-A1 NOVEL REVAMIPIDE PRODRUGS, PREPARATION METHOD AND USE THEREOF ASTECH. CO., LTD. (KR) 2015-05-21 US claimed
EP-2865669-A1 NOVEL REBAMIPIDE PRODRUG, METHOD FOR PRODUCING SAME, AND USAGE THEREOF Samjin Pharmaceutical Co., Ltd. (KR) 2015-04-29 EP claimed
US-11420963-B2 Rebamipide prodrugs, preparation method and use thereof SAMJIN PHARMACEUTICAL CO., LTD. (KR) 2022-08-23 US disclosed
EP-2865669-B1 NOVEL REBAMIPIDE PRODRUG, METHOD FOR PRODUCING SAME, AND USAGE THEREOF SAMJIN PHARM CO LTD (KR) 2021-04-28 EP disclosed
EP-2865669-B1 NOVEL REBAMIPIDE PRODRUG, METHOD FOR PRODUCING SAME, AND USAGE THEREOF SAMJIN PHARM CO LTD (KR) 2021-04-28 EP disclosed
US-20150141409-A1 NOVEL REVAMIPIDE PRODRUGS, PREPARATION METHOD AND USE THEREOF ASTECH. CO., LTD. (KR) 2015-05-21 US disclosed
US-20150141409-A1 NOVEL REVAMIPIDE PRODRUGS, PREPARATION METHOD AND USE THEREOF ASTECH. CO., LTD. (KR) 2015-05-21 US disclosed
US-20150141409-A1 NOVEL REVAMIPIDE PRODRUGS, PREPARATION METHOD AND USE THEREOF ASTECH. CO., LTD. (KR) 2015-05-21 US disclosed
EP-2865669-A1 NOVEL REBAMIPIDE PRODRUG, METHOD FOR PRODUCING SAME, AND USAGE THEREOF Samjin Pharmaceutical Co., Ltd. (KR) 2015-04-29 EP disclosed
EP-2865669-A1 NOVEL REBAMIPIDE PRODRUG, METHOD FOR PRODUCING SAME, AND USAGE THEREOF Samjin Pharmaceutical Co., Ltd. (KR) 2015-04-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150141409-A1 NOVEL REVAMIPIDE PRODRUGS, PREPARATION METHOD AND USE THEREOF REV1, GRPR, SI UBASH3B 2690/4885TACR1 2155/4885F11 1844/4885
US-11420963-B2 Rebamipide prodrugs, preparation method and use thereof SI, CYP2A7, MLN UBASH3B 3043/4885TACR1 2338/4885F11 1326/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.