Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 5/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.41 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16667013 | 1.00 | ROCK1 (0.48) | ROCK1ROCK2ENPP2CCR2BCHE | |
| SCHEMBL16667015 | 0.94 | ENPP2 (0.49) | ROCK1ENPP2KCNH2S1PR5 | |
| SCHEMBL17997523 | 0.93 | ENPP2 (0.47) | ENPP2KCNH2S1PR5 | |
| SCHEMBL16667001 | 0.91 | ENPP2 (0.53) | ROCK1ENPP2S1PR5NPC1L1 | |
| SCHEMBL16667317 | 0.88 | ENPP2 (0.50) | ROCK1ROCK2ENPP2CCR2KCNH2 | |
| SCHEMBL17997536 | 0.88 | ENPP2 (0.50) | ROCK1ROCK2ENPP2CCR2KCNH2 | |
| SCHEMBL1161518 | 0.88 | ENPP2 (0.54) | ENPP2POLBS1PR5 | |
| SCHEMBL11029479 | 0.88 | ENPP2 (0.54) | ENPP2POLBS1PR5 | |
| SCHEMBL21154821 | 0.88 | ENPP2 (0.54) | ENPP2POLBS1PR5 | |
| SCHEMBL11029484 | 0.88 | ENPP2 (0.54) | ENPP2POLBS1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2461683-B1 | BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS | BIOGEN IDEC INC (US) | 2015-04-29 | — | — | EP | claimed |