Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 7/20 | 0.50 |
| ▸ | CCR3 | P51677 | 2/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16667317 | 1.00 | ENPP2 (0.50) | ENPP2CCR3S1PR5MEN1KMT2A | |
| SCHEMBL17997523 | 0.96 | ENPP2 (0.47) | ENPP2CCR3S1PR5MEN1KMT2A | |
| SCHEMBL16667015 | 0.94 | ENPP2 (0.49) | ENPP2CCR3S1PR5MEN1KMT2A | |
| SCHEMBL16667001 | 0.91 | ENPP2 (0.53) | ENPP2CCR3S1PR5ROCK1 | |
| SCHEMBL17997517 | 0.90 | ENPP2 (0.59) | ENPP2CCR3MEN1KMT2AHRH1 | |
| SCHEMBL11027934 | 0.89 | S1PR5 (0.60) | ENPP2S1PR5MCHR1 | |
| SCHEMBL11027922 | 0.89 | S1PR5 (0.60) | ENPP2S1PR5MCHR1 | |
| SCHEMBL12471153 | 0.89 | S1PR5 (0.60) | ENPP2S1PR5MCHR1 | |
| SCHEMBL16667103 | 0.88 | ROCK1 (0.48) | ENPP2S1PR5KCNH2ROCK2CCR2 | |
| SCHEMBL16667013 | 0.88 | ROCK1 (0.48) | ENPP2S1PR5KCNH2ROCK2CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3150590-B1 | S1P MODULATING AGENTS | BIOGEN MA INC (US) | 2019-10-16 | — | — | EP | claimed |
| EP-2672823-B1 | S1P MODULATING AGENTS | BIOGEN MA INC (US) | 2016-08-24 | — | — | EP | claimed |