Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 8/20 | 0.53 |
| ▸ | S1PR5 | Q9H228 | 7/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16667015 | 0.93 | ENPP2 (0.49) | ENPP2S1PR5CCR3ROCK1 | |
| SCHEMBL16667013 | 0.91 | ROCK1 (0.48) | ENPP2S1PR5NPC1L1ROCK1 | |
| SCHEMBL16667103 | 0.91 | ROCK1 (0.48) | ENPP2S1PR5NPC1L1ROCK1 | |
| SCHEMBL17997536 | 0.91 | ENPP2 (0.50) | ENPP2S1PR5CCR3ROCK1 | |
| SCHEMBL16667317 | 0.91 | ENPP2 (0.50) | ENPP2S1PR5CCR3ROCK1 | |
| SCHEMBL1161649 | 0.88 | ENPP2 (0.61) | ENPP2S1PR5 | |
| SCHEMBL1161647 | 0.88 | ENPP2 (0.61) | ENPP2S1PR5 | |
| SCHEMBL11942487 | 0.88 | ENPP2 (0.61) | ENPP2S1PR5 | |
| SCHEMBL11942415 | 0.88 | ENPP2 (0.61) | ENPP2S1PR5 | |
| SCHEMBL16667132 | 0.88 | ENPP2 (0.51) | ENPP2S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2461683-B1 | BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS | BIOGEN IDEC INC (US) | 2015-04-29 | — | — | EP | claimed |