Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | STAT6 | P42226 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 2/20 | 0.37 |
| ▸ | CCND1 | P24385 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1666777 | 0.90 | MAOB (0.44) | ROCK2ITGB3ITGA2BMAPK10MAPK8 | |
| SCHEMBL1664050 | 0.86 | DHODH (0.42) | ROCK2STAT6SYKNTSR1ITGB3 | |
| SCHEMBL1665348 | 0.83 | TNIK (0.42) | MAPK10MAPK8MAPK13MAPK12MAPK11 | |
| SCHEMBL1666178 | 0.83 | MAPK10 (0.41) | MAPK10MAPK8MAPK13MAPK12MAPK11 | |
| SCHEMBL11963718 | 0.81 | NR3C1 (0.49) | STAT6SYKMAPK10MAPK8MAPK13 | |
| SCHEMBL6126370 | 0.80 | DHODH (0.39) | STAT6SYKNTSR1PIN1TNIK | |
| SCHEMBL1665351 | 0.79 | MAOB (0.42) | ROCK2MAPK10MAPK8MAPK13MAPK12 | |
| SCHEMBL1664246 | 0.79 | SYK (0.44) | ROCK2STAT6SYKMAPK10MAPK8 | |
| SCHEMBL1664617 | 0.79 | MAOB (0.45) | MAPK10MAPK8MAPK13MAPK12MAPK11 | |
| SCHEMBL1663875 | 0.79 | TDP1 (0.47) | MAPK10MAPK8MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |