Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 6/20 | 0.35 |
| ▸ | ACP1 | P24666 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8667048 | 0.81 | CYP1A2 (0.41) | MAPTL3MBTL1KDM4ELMNAALDH1A1 | |
| SCHEMBL2449378 | 0.80 | SMN1; SMN2 (0.32) | — | |
| SCHEMBL8664655 | 0.78 | CYP1A2 (0.33) | KMT2AMAPTL3MBTL1LMNAALDH1A1 | |
| SCHEMBL1665147 | 0.77 | IDO1 (0.39) | IDO1ESR1ACP1TLR7KMT2A | |
| SCHEMBL343994 | 0.77 | — | — | |
| SCHEMBL8666664 | 0.77 | CYP1A2 (0.33) | KMT2AMAPTL3MBTL1LMNAALDH1A1 | |
| SCHEMBL8668377 | 0.74 | LMNA (0.54) | KMT2AMAPTL3MBTL1GAALMNA | |
| SCHEMBL2182651 | 0.73 | IDO1 (0.38) | IDO1TLR7KMT2AL3MBTL1KDM4E | |
| SCHEMBL1664327 | 0.73 | ESR1 (0.35) | IDO1ESR1HRH4 | |
| SCHEMBL5472820 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231602-A1 | GAMMA SECRETASE MODULATORS | Amgen, Inc (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009075874-A1 | GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-06-18 | — | — | WO | claimed |
| US-8022072-B2 | Azolylmethylidenehydrazine derivative and use thereof | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2011-09-20 | — | — | US | disclosed |
| US-20110166132-A1 | Gamma Secretase Modulators | AMGEN INC. (US) | 2011-07-07 | — | — | US | disclosed |
| US-7968019-B2 | Optical compensation film, method for producing optical compensation film, polarization plate and liquid crystal display | KONICA MINOLTA OPTO, INC. (JP) | 2011-06-28 | — | — | US | disclosed |
| US-7922947-B2 | Method of producing dispersion | FUJIFILM CORPORATION (JP) | 2011-04-12 | — | — | US | disclosed |
| EP-2231602-A1 | GAMMA SECRETASE MODULATORS | Amgen, Inc (US) | 2010-09-29 | — | — | EP | disclosed |
| US-20100190754-A1 | AZOLYLMETHYLIDENEHYDRAZINE DERIVATIVE AND USE THEREOF | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2010-07-29 | — | — | US | disclosed |
| EP-2168951-A1 | AZOLYLMETHYLENEHYDRAZINE DERIVATIVE AND USE THEREOF | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2010-03-31 | — | — | EP | disclosed |
| WO-2009075874-A1 | GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-06-18 | — | — | WO | disclosed |
| US-7166339-B1 | Phase contrast plate comprising one sheet of cellulose ester film containing aromatic compound | FUJIFILM CORPORATION (JP) | 2007-01-23 | — | — | US | disclosed |
| US-20060216437-A1 | Optical compensation film, method for producing optical compensation film, polarization plate and liquid crystal display | KONICA MINOLTA OPTO, INC. (JP) | 2006-09-28 | — | — | US | disclosed |
| US-20050062193-A1 | Method of producing dispersion | FUJIFILM CORPORATION (JP) | 2005-03-24 | — | — | US | disclosed |
| CN-1173198-C | Phase retardation plate comprising cellulose ester film, circularly polarizing plate and liquid crystal display device | 富士胶片株式会社 | 2004-10-27 | — | — | CN | disclosed |
| EP-1425283-A1 | NOVEL 4-AMINOFUROPYRIMIDINES AND THE USE THEREOF | Bayer HealthCare AG (DE) | 2004-06-09 | — | — | EP | disclosed |
| US-6630973-B1 | Compensatory sheet, ellipsoidal polarizing plate and liquid crystal display. | FUJI PHOTO FILM CO., LTD. (JP) | 2003-10-07 | — | — | US | disclosed |
| WO-2003018589-A1 | NOVEL 4-AMINOFUROPYRIMIDINES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2003-03-06 | — | — | WO | disclosed |
| EP-1182470-A1 | PHASE CONTRAST PLATE COMPRISING ONE SHEET OF CELLULOSE ESTER FILM CONTAINING AROMATIC COMPOUND | FUJI PHOTO FILM CO., LTD. (JP) | 2002-02-27 | — | — | EP | disclosed |
| US-5750552-A | ANTIULCER AGENTS | ARAX CO., LTD. (JP) | 1998-05-12 | — | — | US | disclosed |
| EP-0736527-A1 | Imadazoline derivative, possible tautomer thereof, process of manufacturing therefor, and vulnerary including such derivative or tautomer | ARAX CO., LTD. (JP) | 1996-10-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166132-A1 | Gamma Secretase Modulators | BACE1, BACE2, PSEN1 | IDO1 4594/4885ESR1 1949/4885ACP1 942/4885 |
| US-20100190754-A1 | AZOLYLMETHYLIDENEHYDRAZINE DERIVATIVE AND USE THEREOF | ARSA, AHR, HRH2 | IDO1 10/4885ESR1 2315/4885ACP1 3960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.