Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16670340 | 0.80 | ITGB1 (0.43) | MEN1KMT2AITGB1ITGA4GAA | |
| SCHEMBL16583355 | 0.74 | MEN1 (0.44) | MEN1KMT2AITGB1ITGA4GAA | |
| SCHEMBL3718009 | 0.73 | SMN1; SMN2 (0.52) | MEN1KMT2AHTTRAB9ANPC1 | |
| SCHEMBL30739749 | 0.72 | JAK2 (0.71) | MEN1KMT2AGAAJAK2JAK1 | |
| SCHEMBL16583943 | 0.72 | GAA (0.59) | MEN1KMT2AITGB1ITGA4GAA | |
| SCHEMBL16677246 | 0.70 | F2R (0.49) | MEN1KMT2AGAAJAK2JAK1 | |
| SCHEMBL16583403 | 0.69 | LMNA (0.48) | MEN1KMT2AITGB1ITGA4GAA | |
| SCHEMBL16584740 | 0.69 | F10 (0.43) | MEN1KMT2AITGB1ITGA4GAA | |
| SCHEMBL28326824 | 0.67 | KMT2A (0.73) | MEN1KMT2AGAAJAK2JAK1 | |
| SCHEMBL19576319 | 0.67 | GAA (0.43) | MEN1KMT2AITGB1ITGA4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015061204-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. (US) | 2015-04-30 | — | — | WO | claimed |
| WO-2015061204-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. (US) | 2015-04-30 | — | — | WO | disclosed |