Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 14/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 14/20 | 0.51 |
| ▸ | DPP4 | P27487 | 3/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.47 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.47 |
| ▸ | APLNR | P35414 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19328264 | 0.88 | OPRK1 (0.50) | OPRM1OPRK1DPP4DPP7DPP8 | |
| SCHEMBL16670121 | 0.87 | OPRM1 (0.53) | OPRM1OPRK1APLNR | |
| SCHEMBL16669770 | 0.86 | OPRM1 (0.57) | OPRM1OPRK1DPP4DPP7DPP8 | |
| SCHEMBL30909434 | 0.85 | OPRM1 (0.61) | OPRM1OPRK1APLNR | |
| SCHEMBL15182357 | 0.85 | OPRM1 (0.64) | OPRM1OPRK1APLNR | |
| SCHEMBL2194031 | 0.85 | NPY4R (0.48) | OPRM1OPRK1DPP4DPP7DPP8 | |
| SCHEMBL19328259 | 0.80 | OPRM1 (0.46) | OPRM1OPRK1APLNR | |
| SCHEMBL15214200 | 0.79 | OPRM1 (0.52) | OPRM1OPRK1APLNR | |
| SCHEMBL3043173 | 0.78 | NPY4R (0.47) | OPRM1OPRK1 | |
| SCHEMBL29607129 | 0.78 | OPRM1 (0.55) | OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10155789-B2 | Substrates and inhibitors of prolyl oligopeptidase and methods of use thereof | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2018-12-18 | — | — | US | disclosed |
| US-20170260231-A1 | Substrates and Inhibitors of Prolyl Oligopeptidase and Methods of Use Thereof | UNIV OKLAHOMA (US) | 2017-09-14 | — | — | US | disclosed |
| US-9688722-B2 | Substrates and inhibitors of prolyl oligopeptidase and methods of use | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2017-06-27 | — | — | US | disclosed |
| US-20150119330-A1 | SUBSTRATES AND INHIBITORS OF PROLYL OLIGOPEPTIDASE AND FIBROBLAST ACTIVATION PROTEIN AND METHODS OF USE | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA | 2015-04-30 | — | — | US | disclosed |