Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28114927 | 0.83 | HPGD (0.52) | HPGDCYP1A2CYP3A4CYP2C19FLT1 | |
| SCHEMBL16042729 | 0.82 | HPGD (0.51) | HPGDCYP1A2CYP3A4CYP2C19FLT1 | |
| SCHEMBL8842593 | 0.78 | HPGD (0.51) | HPGDCYP1A2CYP3A4CYP2C19FLT1 | |
| SCHEMBL1799899 | 0.78 | VCAM1 (0.51) | MAPK1RAB9AVCAM1 | |
| SCHEMBL11270931 | 0.78 | HPGD (0.50) | HPGDCYP1A2CYP3A4CYP2C19FLT1 | |
| SCHEMBL848335 | 0.77 | HPGD (0.56) | HPGDCYP1A2CYP3A4CYP2C19FLT1 | |
| SCHEMBL29758067 | 0.77 | HPGD (0.56) | HPGDCYP1A2CYP3A4CYP2C19FLT1 | |
| SCHEMBL11301098 | 0.76 | HPGD (0.59) | HPGDCYP1A2CYP3A4CYP2C19FLT1 | |
| SCHEMBL11687524 | 0.76 | HPGD (0.49) | HPGDCYP1A2CYP3A4CYP2C19FLT1 | |
| SCHEMBL5548331 | 0.76 | VCAM1 (0.54) | HPGDMAPK1ALDH1A1NPSR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150119402-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | UNIV CALIFORNIA (US) | 2015-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150119402-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | CHRNA7, CHRNA1, CHRNA2 | HPGD 1602/4885CYP1A2 1898/4885CYP3A4 2069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.