Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 19/20 | 0.57 |
| ▸ | DPP7 | Q9UHL4 | 13/20 | 0.57 |
| ▸ | DPP8 | Q6V1X1 | 9/20 | 0.57 |
| ▸ | FAP | Q12884 | 8/20 | 0.57 |
| ▸ | DPP9 | Q86TI2 | 8/20 | 0.57 |
| ▸ | PREP | P48147 | 4/20 | 0.57 |
| ▸ | PITRM1 | Q5JRX3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10057905 | 0.87 | DPP4 (0.59) | DPP4DPP7DPP8FAPDPP9 | |
| SCHEMBL2769142 | 0.87 | DPP4 (0.59) | DPP4DPP7DPP8FAPDPP9 | |
| SCHEMBL12001763 | 0.86 | ACE (0.41) | DPP4DPP7DPP8FAPDPP9 | |
| SCHEMBL24448586 | 0.84 | DPP4 (0.63) | DPP4DPP7DPP8FAPDPP9 | |
| SCHEMBL17760537 | 0.84 | DPP4 (0.63) | DPP4DPP7DPP8FAPDPP9 | |
| SCHEMBL13437289 | 0.84 | FAP (0.44) | DPP4DPP7DPP8FAPDPP9 | |
| SCHEMBL15375186 | 0.83 | DPP4 (0.64) | DPP4DPP7DPP8FAPDPP9 | |
| SCHEMBL20987818 | 0.83 | DPP4 (0.40) | DPP4DPP7DPP8FAPDPP9 | |
| SCHEMBL16281602 | 0.83 | DPP4 (0.40) | DPP4DPP7DPP8FAPDPP9 | |
| SCHEMBL15779984 | 0.83 | ACE (0.40) | DPP4DPP7DPP8FAPDPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9688722-B2 | Substrates and inhibitors of prolyl oligopeptidase and methods of use | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2017-06-27 | — | — | US | disclosed |
| US-9527884-B2 | Substrates and inhibitors of antiplasmin cleaving enzyme and fibroblast activation protein and methods of use | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2016-12-27 | — | — | US | disclosed |
| US-20150141660-A1 | Substrates and Inhibitors of Antiplasmin Cleaving Enzyme and Fibroblast Activation Protein and Methods of Use | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-05-21 | — | — | US | disclosed |
| US-20150119330-A1 | SUBSTRATES AND INHIBITORS OF PROLYL OLIGOPEPTIDASE AND FIBROBLAST ACTIVATION PROTEIN AND METHODS OF USE | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA | 2015-04-30 | — | — | US | disclosed |