Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 19/20 | 0.59 |
| ▸ | DPP7 | Q9UHL4 | 11/20 | 0.59 |
| ▸ | FAP | Q12884 | 7/20 | 0.59 |
| ▸ | DPP8 | Q6V1X1 | 7/20 | 0.59 |
| ▸ | DPP9 | Q86TI2 | 6/20 | 0.59 |
| ▸ | PREP | P48147 | 4/20 | 0.59 |
| ▸ | PITRM1 | Q5JRX3 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10057905 | 1.00 | DPP4 (0.59) | DPP4DPP7FAPDPP8DPP9 | |
| SCHEMBL16670795 | 0.87 | DPP4 (0.57) | DPP4DPP7FAPDPP8DPP9 | |
| SCHEMBL15375186 | 0.86 | DPP4 (0.64) | DPP4DPP7FAPDPP8DPP9 | |
| SCHEMBL20987818 | 0.83 | DPP4 (0.40) | DPP4DPP7FAPDPP8DPP9 | |
| SCHEMBL16281602 | 0.83 | DPP4 (0.40) | DPP4DPP7FAPDPP8DPP9 | |
| SCHEMBL12001763 | 0.83 | ACE (0.41) | DPP4DPP7FAPDPP8DPP9 | |
| SCHEMBL23667668 | 0.83 | DPP4 (0.60) | DPP4DPP7FAPDPP8DPP9 | |
| SCHEMBL8097043 | 0.83 | DPP4 (0.60) | DPP4DPP7FAPDPP8DPP9 | |
| SCHEMBL28570897 | 0.82 | DPP4 (0.64) | DPP4DPP7FAPDPP8DPP9 | |
| SCHEMBL24448586 | 0.81 | DPP4 (0.63) | DPP4DPP7FAPDPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675578-B9 | INHIBITORS OF GLUTAMINYL AND GLUTAMATE CYCLASES FOR THE TREATMENT OF THE NEURODEGENERATIVE DISEASES FBD AND FDD | PROBIODRUG AG (DE) | 2014-06-25 | — | — | EP | claimed |
| EP-1675578-B1 | INHIBITORS OF GLUTAMINYL AND GLUTAMATE CYCLASES FOR THE TREATMENT OF THE NEURODEGENERATIVE DISEASES FBD AND FDD | PROBIODRUG AG (DE) | 2013-05-22 | — | — | EP | claimed |
| CN-102302781-A | Medical use of inhibitors of glutaminyl and glutamate cyclases | PROBIODRUG AG | 2012-01-04 | — | — | CN | claimed |
| CN-1784220-B | Use of effectors of glutaminyl and glutamate cyclases | PROBIODRUG AG | 2011-08-03 | — | — | CN | claimed |
| CN-101837127-A | The application of glutaminyl and glutamate cyclase effector | PROBIODRUG AG | 2010-09-22 | — | — | CN | claimed |
| EP-1620082-B9 | MEDICAL USE OF INHIBITORS OF GLUTAMINYL AND GLUTAMATE CYCLASES FOR TREATING ALZHEIMER'S DISEASE AND DOWN SYNDROME | PROBIODRUG AG (DE) | 2010-08-25 | — | — | EP | claimed |
| EP-1620082-B1 | MEDICAL USE OF INHIBITORS OF GLUTAMINYL AND GLUTAMATE CYCLASES FOR TREATING ALZHEIMER'S DISEASE AND DOWN SYNDROME | PROBIODRUG AG (DE) | 2010-04-21 | — | — | EP | claimed |
| EP-0896538-B1 | USE OF ACTIVITY INHIBITING DIPEPTIDYL PEPTIDASE IV EFFECTORS FOR LOWERING THE BLOOD GLUCOSE LEVEL IN MAMMALS | PROBIODRUG GES FUER ARZNEIM (DE) | 2001-07-04 | — | — | EP | claimed |
| CN-102302781-A | Medical use of inhibitors of glutaminyl and glutamate cyclases | PROBIODRUG AG | 2012-01-04 | — | — | CN | disclosed |
| CN-1784220-B | Use of effectors of glutaminyl and glutamate cyclases | PROBIODRUG AG | 2011-08-03 | — | — | CN | disclosed |
| CN-101837127-A | The application of glutaminyl and glutamate cyclase effector | PROBIODRUG AG | 2010-09-22 | — | — | CN | disclosed |
| CN-1867324-A | Use of effectors of glutaminyl and glutamate cyclases | PROBIODRUG AG (DE) | 2006-11-22 | — | — | CN | disclosed |
| CN-1784220-A | Use of effectors of glutaminyl and glutamate cyclases | PROBIODRUG AG (DE) | 2006-06-07 | — | — | CN | disclosed |
| US-20020071838-A1 | Method for raising the blood glucose level in mammals | PROSIDION LIMITED (GB) | 2002-06-13 | — | — | US | disclosed |
| US-6319893-B1 | Raising blood sugar level in hypoglycemic mammals by administering inhibitors of dipeptidyl peptidase IV | PROBIODRUG (DE) | 2001-11-20 | — | — | US | disclosed |