Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.50 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | UBE2M | P61081 | 1/20 | 0.49 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RHOA | P61586 | 2/20 | 0.47 |
| ▸ | RHOC | P08134 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22633108 | 1.00 | RAB9A (0.53) | RAB9AALDH1A1NPC1HCRTR1HCRTR2 | |
| SCHEMBL17511351 | 0.92 | RAB9A (0.52) | RAB9AALDH1A1NPC1HCRTR1HCRTR2 | |
| SCHEMBL19433798 | 0.88 | LMNA (0.53) | RAB9AALDH1A1NPC1HCRTR1HCRTR2 | |
| SCHEMBL29458358 | 0.88 | LMNA (0.53) | RAB9AALDH1A1NPC1HCRTR1HCRTR2 | |
| SCHEMBL28589348 | 0.87 | RAB9A (0.61) | RAB9AALDH1A1NPC1HCRTR1HCRTR2 | |
| SCHEMBL28589349 | 0.87 | RAB9A (0.61) | RAB9AALDH1A1NPC1HCRTR1HCRTR2 | |
| SCHEMBL18045227 | 0.87 | RAB9A (0.48) | RAB9AALDH1A1NPC1HCRTR1HCRTR2 | |
| SCHEMBL16677931 | 0.86 | USP2 (0.57) | RAB9AALDH1A1NPC1HCRTR1HCRTR2 | |
| SCHEMBL16671636 | 0.86 | USP2 (0.57) | RAB9AALDH1A1NPC1HCRTR1HCRTR2 | |
| SCHEMBL22633023 | 0.86 | MALT1 (0.65) | ALDH1A1SMN1; SMN2UBE2MDCUN1D1MALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10377709-B2 | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B | JANSSEN SCIENCES IRELAND UC (IE) | 2019-08-13 | — | — | US | disclosed |
| US-10071961-B2 | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B | JANSSEN SCIENCES IRELAND UC (IE) | 2018-09-11 | — | — | US | disclosed |
| US-9567299-B2 | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B | JANSSEN SCIENCES IRELAND UC (IE) | 2017-02-14 | — | — | US | disclosed |
| US-20160264522-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN INFECTIOUS DISEASES BVBA (BE) | 2016-09-15 | — | — | US | disclosed |
| EP-3060547-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | Janssen Sciences Ireland UC (IE) | 2016-08-31 | — | — | EP | disclosed |
| WO-2015059212-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN R&D IRELAND (IE) | 2015-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10071961-B2 | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B | HCCS, NR1H4, GLS2 | RAB9A 3418/4885ALDH1A1 2629/4885NPC1 1066/4885 |
| US-10377709-B2 | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B | HCCS, XDH, NR1H4 | RAB9A 3354/4885ALDH1A1 2810/4885NPC1 1185/4885 |
| US-20160264522-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | HCCS, XDH, NR1H4 | RAB9A 3354/4885ALDH1A1 2810/4885NPC1 1185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.