Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 11/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1667300 | 0.92 | HPGDS (0.51) | HPGDSMAPK10MAPK8MAPK13MAPK12 | |
| SCHEMBL6126142 | 0.89 | HPGDS (0.50) | HPGDS | |
| SCHEMBL6126144 | 0.86 | HPGDS (0.49) | HPGDSTNIK | |
| SCHEMBL13964715 | 0.86 | NPC1 (0.50) | HPGDSMAPK10MAPK8MAPK13MAPK12 | |
| SCHEMBL1664617 | 0.85 | MAOB (0.45) | MAPK10MAPK8MAPK13MAPK12MAPK11 | |
| SCHEMBL1666867 | 0.84 | MAPK10 (0.44) | MAPK10MAPK8MAPK13MAPK12MAPK11 | |
| SCHEMBL6126290 | 0.84 | CHRNA7 (0.51) | MAPK10MAPK8MAPK13MAPK12MAPK11 | |
| SCHEMBL1664303 | 0.83 | MAPK10 (0.45) | MAPK10MAPK8MAPK13MAPK12MAPK11 | |
| SCHEMBL1665212 | 0.83 | NPC1 (0.53) | MAPK10MAPK8MAPK13MAPK12MAPK11 | |
| SCHEMBL1666461 | 0.82 | MAPT (0.50) | MAPK10MAPK8MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |