Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 3/20 | 0.45 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.45 |
| ▸ | XDH | P47989 | 4/20 | 0.45 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.44 |
| ▸ | PPID | Q08752 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1669891 | 0.88 | IKBKE (0.57) | IKBKETBK1 | |
| SCHEMBL1667238 | 0.88 | XDH (0.48) | IKBKETBK1XDHAAK1PPID | |
| SCHEMBL1667333 | 0.84 | XDH (0.47) | IKBKETBK1XDHAAK1 | |
| SCHEMBL1667110 | 0.84 | TBK1 (0.63) | IKBKETBK1 | |
| SCHEMBL13279037 | 0.81 | IKBKE (0.48) | IKBKETBK1XDHAAK1 | |
| SCHEMBL1667237 | 0.80 | XDH (0.47) | IKBKETBK1XDHAAK1PPID | |
| SCHEMBL1667719 | 0.79 | XDH (0.45) | IKBKETBK1XDHAAK1 | |
| SCHEMBL1667257 | 0.77 | JAK2 (0.52) | IKBKETBK1AAK1 | |
| SCHEMBL1667222 | 0.76 | IKBKE (0.50) | IKBKETBK1XDHAAK1 | |
| SCHEMBL1667294 | 0.76 | IKBKE (0.60) | IKBKETBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488503-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | Myrexis, Inc. (US) | 2012-08-22 | — | — | EP | claimed |
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | claimed |
| EP-2488503-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | Myrexis, Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |