Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | G6PD | P11413 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MPI | P34949 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15522833 | 0.85 | LMNA (0.54) | LMNATP53ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL1667091 | 0.82 | NPC1 (0.51) | LMNAALDH1A1CYP2C19MAPTMEN1 | |
| SCHEMBL1667486 | 0.80 | LMNA (0.49) | LMNATP53ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL27868016 | 0.80 | MAPK1 (0.56) | LMNATP53ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL7508636 | 0.80 | MAPK1 (0.56) | LMNATP53ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL13447325 | 0.80 | MAPK1 (0.58) | LMNATP53ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL1669859 | 0.79 | MEN1 (0.54) | LMNATP53ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL8828727 | 0.77 | MEN1 (0.61) | LMNATP53ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL30831449 | 0.77 | LMNA (0.57) | LMNATP53ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL13807662 | 0.74 | MEN1 (0.61) | LMNATP53ALDH1A1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2482815-A1 | ANTI INFLAMMATORY 2-OXOTHIAZOLES AND 2 -OXOOXAZOLES | Avexxin AS (NO) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011039365-A1 | ANTI INFLAMMATORY 2-OXOTHIAZOLES AND 2 -OXOOXAZOLES | AVEXXIN AS (NO) | 2011-04-07 | — | — | WO | disclosed |