Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.51 |
| ▸ | RAB9A | P51151 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 4/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1667487 | 0.82 | LMNA (0.49) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL3647336 | 0.80 | RAB9A (0.56) | NPC1RAB9AMAPTSMN1; SMN2HSP90AA1 | |
| SCHEMBL1667088 | 0.80 | PLA2G4A (0.48) | NPC1RAB9AMAPTSMN1; SMN2HSP90AA1 | |
| SCHEMBL27868000 | 0.79 | PLA2G4A (0.57) | NPC1RAB9AMAPTSMN1; SMN2HSP90AA1 | |
| SCHEMBL14000058 | 0.79 | PLA2G4A (0.57) | NPC1RAB9AMAPTSMN1; SMN2HSP90AA1 | |
| SCHEMBL16399172 | 0.79 | PLA2G4A (0.57) | NPC1RAB9AMAPTSMN1; SMN2HSP90AA1 | |
| SCHEMBL2142396 | 0.79 | RAB9A (0.57) | NPC1RAB9AMAPTSMN1; SMN2HSP90AA1 | |
| SCHEMBL15349050 | 0.79 | RAB9A (0.55) | NPC1RAB9AMAPTSMN1; SMN2HSP90AA1 | |
| SCHEMBL1667067 | 0.78 | RAB9A (0.54) | NPC1RAB9AMAPTSMN1; SMN2HSP90AA1 | |
| SCHEMBL5669977 | 0.78 | RAB9A (0.54) | NPC1RAB9AMAPTSMN1; SMN2HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2482815-A1 | ANTI INFLAMMATORY 2-OXOTHIAZOLES AND 2 -OXOOXAZOLES | Avexxin AS (NO) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011039365-A1 | ANTI INFLAMMATORY 2-OXOTHIAZOLES AND 2 -OXOOXAZOLES | AVEXXIN AS (NO) | 2011-04-07 | — | — | WO | disclosed |