Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15533384 | 0.81 | ALDH1A1 (0.48) | NPC1NOTUMPTPN1TDP1 | |
| SCHEMBL9178263 | 0.77 | ALDH1A1 (0.50) | LMNANPC1SMN1; SMN2MAPTHTT | |
| SCHEMBL3084334 | 0.76 | NPC1 (0.68) | NPC1NOTUMSMN1; SMN2MAPTHTT | |
| SCHEMBL9175899 | 0.74 | KCNA3 (0.45) | KCNA3KCNQ2NOTUMMAPTCSF1R | |
| SCHEMBL4313452 | 0.73 | HPGD (0.45) | LMNANPC1MAPK1SMN1; SMN2MAPT | |
| SCHEMBL11220957 | 0.72 | LMNA (0.37) | LMNACES2CES1KCNQ2MAPK1 | |
| SCHEMBL10428607 | 0.71 | LMNA (0.61) | LMNACES2CES1MAPK1SMN1; SMN2 | |
| SCHEMBL1078400 | 0.71 | TLR9 (0.58) | LMNACES2CES1MAPK1HTT | |
| SCHEMBL5051768 | 0.70 | LMNA (0.50) | LMNACES2CES1MAPK1SMN1; SMN2 | |
| SCHEMBL29627850 | 0.70 | NOTUM (0.50) | LMNANOTUMMAPTPTPN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |