Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 2/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.39 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | PTGIR | P43119 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15295224 | 1.00 | ACLY (0.46) | ACLYPTGDR2EPHA2KDREPHB4 | |
| SCHEMBL15287441 | 0.94 | ACLY (0.44) | ACLYPTGDR2EPHA2KDREPHB4 | |
| SCHEMBL4014930 | 0.93 | ACLY (0.51) | ACLYPTGDR2EPHA2KDREPHB4 | |
| SCHEMBL4318896 | 0.93 | ACLY (0.51) | ACLYPTGDR2EPHA2KDREPHB4 | |
| SCHEMBL15287559 | 0.92 | ACLY (0.49) | ACLYPTGDR2EPHA2KDREPHB4 | |
| SCHEMBL15295335 | 0.89 | ACLY (0.42) | ACLYPTGDR2EPHA2KDREPHB4 | |
| SCHEMBL16675380 | 0.89 | ACLY (0.45) | ACLYPTGDR2EPHA2KDREPHB4 | |
| SCHEMBL15295148 | 0.89 | ACLY (0.45) | ACLYPTGDR2EPHA2KDREPHB4 | |
| SCHEMBL16675385 | 0.89 | ACLY (0.42) | ACLYPTGDR2EPHA2KDREPHB4 | |
| SCHEMBL15295154 | 0.89 | ACLY (0.42) | ACLYPTGDR2EPHA2KDREPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150119394-A1 | Insulin-Like Growth Factor-1 Receptor Inhibitors | MERCK SHARP & DOHME CORP. | 2015-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150119394-A1 | Insulin-Like Growth Factor-1 Receptor Inhibitors | IGF1R, IGFBP1, INSR | ACLY 1860/4885PTGDR2 1387/4885EPHA2 1559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.