Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16900683 | 0.76 | IDO1 (0.33) | TSHRALDH1A1HSD17B10CYP3A4TDP1 | |
| SCHEMBL30627908 | 0.76 | ALDH1A1 (0.40) | TSHRALDH1A1HSD17B10CYP3A4TDP1 | |
| SCHEMBL3736685 | 0.76 | ALDH1A1 (0.40) | TSHRALDH1A1HSD17B10CYP3A4TDP1 | |
| SCHEMBL1039636 | 0.75 | GAA (0.54) | TSHRALDH1A1HSD17B10CYP3A4TDP1 | |
| SCHEMBL11052434 | 0.74 | HTT (0.39) | TSHRALDH1A1HSD17B10CYP3A4TDP1 | |
| SCHEMBL14702114 | 0.73 | TSHR (0.46) | TSHRALDH1A1HSD17B10CYP3A4TDP1 | |
| SCHEMBL16914828 | 0.73 | HTT (0.47) | TSHRALDH1A1HSD17B10CYP3A4TDP1 | |
| SCHEMBL11811760 | 0.71 | ALDH1A1 (0.42) | TSHRALDH1A1CYP3A4TDP1TP53 | |
| SCHEMBL11741152 | 0.70 | FSCN1 (0.53) | TSHRALDH1A1HSD17B10CYP3A4TDP1 | |
| SCHEMBL5797586 | 0.70 | SIGMAR1 (0.44) | TSHRALDH1A1HSD17B10CYP3A4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150119571-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-04-30 | — | — | US | disclosed |
| US-20150119571-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150119571-A1 | NEPRILYSIN INHIBITORS | MME, REN, ACE | TSHR 1047/4885ALDH1A1 2394/4885HSD17B10 4111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.