Sugi Predict

Sugi Predict / Compounds / SCHEMBL16675462

SCHEMBL16675462

SCHEMBL16675462

COc1ccc(-c2nnc(S)n2N)c(F)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ AMY1A P0DUB6 4/20 0.41
▸ PDE2A O00408 2/20 0.39
▸ PDE10A Q9Y233 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ GRM2 Q14416 2/20 0.38
▸ PRKAB2 O43741 1/20 0.37
▸ PRKAG1 P54619 1/20 0.37
▸ PRKAA2 P54646 1/20 0.37
▸ PRKAA1 Q13131 1/20 0.37
▸ PRKAG3 Q9UGI9 1/20 0.37
▸ PRKAG2 Q9UGJ0 1/20 0.37
▸ PRKAB1 Q9Y478 1/20 0.37
▸ PRKCZ Q05513 1/20 0.37
▸ CD274 Q9NZQ7 1/20 0.37
▸ ERN1 O75460 1/20 0.35
▸ DCTPP1 Q9H773 1/20 0.35
▸ PTGS1 P23219 1/20 0.35
▸ PTGS2 P35354 1/20 0.35
▸ USP7 Q93009 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4346620 0.84 ALDH1A1 (0.56) KDM4EALDH1A1
SCHEMBL4351022 0.81 MEN1 (0.47) PDE10AKDM4EALDH1A1
SCHEMBL25413578 0.80 ALDH1A1 (0.36) PDE2APDE10AKDM4EALDH1A1
SCHEMBL22599822 0.78 HSD11B1 (0.46) PDE2APDE10AALDH1A1GRM2
SCHEMBL4342691 0.77 KDM4E (0.39) PDE2APDE10AKDM4EALDH1A1
SCHEMBL13828022 0.75 MAPT (0.52) ALDH1A1PTGS1PTGS2
SCHEMBL4482344 0.74 LRRK2 (0.38) AMY1APDE2APDE10AKDM4EERN1
SCHEMBL4486268 0.74 ACHE (0.42) KDM4EALDH1A1
SCHEMBL3991262 0.74 TSHR (0.55) KDM4EALDH1A1DCTPP1
SCHEMBL4944318 0.73 ALDH1A1 (0.46) PDE2APDE10AKDM4EALDH1A1DCTPP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11737462-B2 Methods for modulating plant response to environmentally-induced stress HOWARD UNIVERSITY (US) 2023-08-29 — — US disclosed
US-11737462-B2 Methods for modulating plant response to environmentally-induced stress HOWARD UNIVERSITY (US) 2023-08-29 — — US disclosed
US-11576901-B2 Methods for treating viral infection HOWARD UNIVERSITY (US) 2023-02-14 — — US disclosed
US-20200297699-A1 METHODS FOR TREATING VIRAL INFECTION GEORGETOWN UNIVERSITY 2020-09-24 — — US disclosed
US-20150119250-A1 METHODS FOR MODULATING PLANT RESPONSE TO ENVIRONMENTALLY-INDUCED STRESS GEORGETOWN UNIVERSITY 2015-04-30 — — US disclosed
US-20150119250-A1 METHODS FOR MODULATING PLANT RESPONSE TO ENVIRONMENTALLY-INDUCED STRESS GEORGETOWN UNIVERSITY 2015-04-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11737462-B2 Methods for modulating plant response to environmentally-induced stress RACK1, ROS1, HSF1 AMY1A 3119/4885PDE2A 2049/4885PDE10A 2254/4885
US-20150119250-A1 METHODS FOR MODULATING PLANT RESPONSE TO ENVIRONMENTALLY-INDUCED STRESS RACK1, ROS1, HSF1 AMY1A 3119/4885PDE2A 2049/4885PDE10A 2254/4885
US-11576901-B2 Methods for treating viral infection RPL5, RPL35, RPL17 AMY1A 4641/4885PDE2A 4780/4885PDE10A 4815/4885
US-20200297699-A1 METHODS FOR TREATING VIRAL INFECTION RPL5, RPL35, RPL17 AMY1A 4641/4885PDE2A 4780/4885PDE10A 4815/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.