Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | TTR | P02766 | 3/20 | 0.45 |
| ▸ | DTYMK | P23919 | 1/20 | 0.44 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4817687 | 0.86 | ATM (0.52) | TDP1ATMTTRKCNMA1CES2 | |
| SCHEMBL357813 | 0.84 | DTYMK (0.62) | TDP1ATMTTRDTYMKKCNMA1 | |
| SCHEMBL590089 | 0.82 | TDP1 (0.56) | TDP1ATMTTRDTYMKKCNMA1 | |
| SCHEMBL28438281 | 0.82 | DTYMK (0.60) | TDP1ATMTTRDTYMKKCNMA1 | |
| SCHEMBL4647431 | 0.82 | TDP1 (0.56) | TDP1ATMTTRDTYMKKCNMA1 | |
| Potassium Ion SCHEMBL15876053 | 0.82 | TDP1 (0.56) | TDP1ATMTTRDTYMKKCNMA1 | |
| SCHEMBL9193556 | 0.81 | DTYMK (0.46) | TDP1DTYMKCTSDCASP6ALDH1A1 | |
| SCHEMBL9244559 | 0.80 | ALDH1A1 (0.53) | DTYMKCTSDCASP6ALDH1A1TSHR | |
| SCHEMBL16953719 | 0.80 | ATM (0.58) | TDP1ATMTTRDTYMKKCNMA1 | |
| SCHEMBL2243892 | 0.80 | GPR35 (0.56) | TDP1DTYMKCES2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112358487-B | Lappaconitine derivative, and preparation method and application thereof | 中国科学院新疆理化技术研究所 | 2023-08-25 | — | — | CN | claimed |
| WO-2022099937-A1 | LAPPACONITINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | 中国科学院新疆理化技术研究所 | 2022-05-19 | — | — | WO | claimed |
| CN-112358487-A | Lappaconitine derivative and preparation method and application thereof | 中国科学院新疆理化技术研究所 | 2021-02-12 | — | — | CN | claimed |
| CN-112358487-B | Lappaconitine derivative, and preparation method and application thereof | 中国科学院新疆理化技术研究所 | 2023-08-25 | — | — | CN | disclosed |
| CN-110997637-B | Aromatic derivative, preparation method and application thereof in medicine | 保仕健生物科技(上海)有限公司 | 2022-09-27 | — | — | CN | disclosed |
| WO-2022099937-A1 | LAPPACONITINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | 中国科学院新疆理化技术研究所 | 2022-05-19 | — | — | WO | disclosed |
| US-11279697-B2 | Aromatic derivative, preparation method for same, and medical applications thereof | BIOARDIS LLC (US) | 2022-03-22 | — | — | US | disclosed |
| CN-108698982-B | Fluorine atom-containing compound and use thereof | 日产化学工业株式会社 | 2021-07-16 | — | — | CN | disclosed |
| CN-112225675-B | Arylamine compound, liquid crystal aligning agent prepared from arylamine compound, liquid crystal aligning film and liquid crystal display element | 江苏三月科技股份有限公司 | 2021-07-06 | — | — | CN | disclosed |
| CN-112358487-A | Lappaconitine derivative and preparation method and application thereof | 中国科学院新疆理化技术研究所 | 2021-02-12 | — | — | CN | disclosed |
| CN-112225675-A | Arylamine compound, liquid crystal aligning agent prepared from arylamine compound, liquid crystal aligning film and liquid crystal display element | 江苏三月科技股份有限公司 | 2021-01-15 | — | — | CN | disclosed |
| US-5670641-A | 3-(3-aryloxyphenyl)-1-(substituted methyl)-S-triazine-2,4,6-oxo or thiotrione herbicidal agents | AMERICAN CYANAMID COMPANY (US) | 1997-09-23 | — | — | US | disclosed |
| US-5654256-A | PREEMERGENCE, POSTEMERGENCE HERBICIDES | AMERICAN CYANAMID COMPANY (US) | 1997-08-05 | — | — | US | disclosed |
| CN-1148592-A | 3-(3-aryloxy phenylic)-1-(substituted methyl)-S-triazine-2,4,6-oxo- or sulfo-triketone herbicide | AMERICAN CYANAMID CO (US) | 1997-04-30 | — | — | CN | disclosed |
| US-5604180-A | RICE CROPS | AMERICAN CYANAMID COMPANY | 1997-02-18 | — | — | US | disclosed |
| EP-0745595-A1 | 3-(3-Aryloxyphenyl)-1-(substituted methyl)-s-triazine-2,4,6-oxo or thiotrione herbicidal agents | American Cyanamid Company (US) | 1996-12-04 | — | — | EP | disclosed |
| US-5519133-A | CYCLIZATION, ALKYLATION | AMERICAN CYANAMID CO. (US) | 1996-05-21 | — | — | US | disclosed |
| EP-0682007-A1 | Method for the preparation of 4-halo-2'-nitrobutyrophenone | AMERICAN CYANAMID COMPANY (US) | 1995-11-15 | — | — | EP | disclosed |
| US-5414136-A | Method for the preparation of 4-halo-2'-nitrobutyrophenone compounds | AMERICAN CYANAMID (US) | 1995-05-09 | — | — | US | disclosed |
| EP-0114224-A1 | Benzoic-acid esters and method for their preparation | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-08-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11279697-B2 | Aromatic derivative, preparation method for same, and medical applications thereof | FGFR4, FGFR1, FGFR3 | TDP1 1923/4885ATM 652/4885TTR 2370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.