Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.88 |
| ▸ | HMGCR | P04035 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.41 |
| ▸ | CPT2 | P23786 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL28279456 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28247763 | 0.97 | ALDH1A1 (0.83) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL8400312 | 0.97 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL4819877 | 0.97 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL2593972 | 0.97 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL1426398 | 0.97 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL11857836 | 0.97 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL2411531 | 0.97 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL21834714 | 0.97 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL7060057 | 0.97 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115067504-B | Special medical food for intestinal tract preparation and preparation method thereof | 医林营海(江苏)营养科技有限公司 | 2024-04-16 | — | — | CN | disclosed |
| CN-115067504-A | Special medical food for intestinal tract preparation and preparation method thereof | 医林营海(江苏)营养科技有限公司 | 2022-09-20 | — | — | CN | disclosed |
| US-20210379142-A1 | AGONISTS OF GUANYLATE CYCLASE AND THEIR USES | BAUSCH HEALTH COMPANIES INC. (CA) | 2021-12-09 | — | — | US | disclosed |
| US-10967043-B2 | Agonists of guanylate cyclase and their uses | BAUSCH HEALTH IRELAND LIMITED (IE) | 2021-04-06 | — | — | US | disclosed |
| EP-3718557-A2 | GUANYLATE CYCLASE RECEPTOR AGONIST SP-333 FOR USE IN COLONIC CLEANSING | Bausch Health Ireland Limited (IE) | 2020-10-07 | — | — | EP | disclosed |
| US-20200054709-A1 | AGONISTS OF GUANYLATE CYCLASE AND THEIR USES | BAUSCH HEALTH COMPANIES INC. (CA) | 2020-02-20 | — | — | US | disclosed |
| US-10342848-B2 | Agonists of guanylate cyclase and their uses | BAUSCH HEALTH IRELAND LIMITED (IE) | 2019-07-09 | — | — | US | disclosed |
| EP-2314319-B1 | Colon Cleansing Compositions | NORGINE BV (NL) | 2019-05-08 | — | — | EP | disclosed |
| US-20170143789-A1 | AGONISTS OF GUANYLATE CYCLASE AND THEIR USES | BAUSCH HEALTH IRELAND LIMITED (IE) | 2017-05-25 | — | — | US | disclosed |
| US-9545446-B2 | Agonists of guanylate cyclase and their uses | SYNERGY PHARMACEUTICALS, INC. (US) | 2017-01-17 | — | — | US | disclosed |
| US-7658914-B2 | first container containing a dry formulation of polyoxyethylene glycol , ascorbic acid and sodium sulfate, calcium sulfate and sodium chloride, potassium chloride, second container containing dry ascorbic acid or sodium or potassium salt; also contains flavor, sweetener; for colonoscopy preperation | NORGINE BV (NL) | 2010-02-09 | — | — | US | disclosed |
| EP-2014304-A1 | Colon cleansing compositions | Norgine Europe BV (NL) | 2009-01-14 | — | — | EP | disclosed |
| EP-1567193-B1 | COLON CLEANSING COMPOSITIONS | NORGINE EUROPE BV (NL) | 2008-08-13 | — | — | EP | disclosed |
| US-20070116667-A1 | Colon cleansing compositions and methods | NORGINE BV (NL) | 2007-05-24 | — | — | US | disclosed |
| US-20070098764-A1 | Colon cleansing compositions and methods | NORGINE EUROPE BV | 2007-05-03 | — | — | US | disclosed |
| US-20070086978-A1 | Colon cleansing compositions and methods | NORGINE EUROPE BV | 2007-04-19 | — | — | US | disclosed |
| US-7169381-B2 | Aqueous solution of polyoxyethylene glycol , ascorbic acid and electrolyte | NORGINE EUROPE BV (NL) | 2007-01-30 | — | — | US | disclosed |
| EP-1567193-A1 | COLON CLEANSING COMPOSITIONS | Norgine Europe BV (NL) | 2005-08-31 | — | — | EP | disclosed |
| US-20040143005-A1 | Colon cleansing compositions and methods | NORGINE EUROPE BV | 2004-07-22 | — | — | US | disclosed |
| WO-2004037292-A1 | COLON CLEANSING COMPOSITIONS | NORGINE EUROPE BV (NL) | 2004-05-06 | — | — | WO | disclosed |