Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.94 |
| ▸ | HMGCR | P04035 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL116215 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL2593972 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL11519286 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL1426398 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL633793 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL7060057 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL11857836 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL8400312 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL4819877 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL3659 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109659537-A | Citrate assists Fluorin doped ternary nano piece/polypyrrole preparation method and product and application | 上海纳米技术及应用国家工程研究中心有限公司 | 2019-04-19 | — | — | CN | claimed |
| CN-107360857-A | A kind of cultural method of straw mushroom | 徐州龙兴农牧科技发展有限公司 | 2017-11-21 | — | — | CN | claimed |
| EP-2161337-B1 | Process for isolating nucleic acids from a nucleic acid-containing sample and a testkit | FORSCHUNGSZENTRUM JUELICH GMBH (DE) | 2011-09-21 | — | — | EP | claimed |
| US-20030143259-A1 | For therapy of infections of the eye and surrounding tissues | SUN PHARMACEUTICAL INDUSTRIES, INC | 2003-07-31 | — | — | US | claimed |
| CN-110514759-B | Method for detecting azide in candesartan cilexetil | 天地恒一制药股份有限公司 | 2022-05-20 | — | — | CN | disclosed |
| US-10723979-B2 | Dishwashing cleaning composition | THE PROCTER & GAMBLE COMPANY (US) | 2020-07-28 | — | — | US | disclosed |
| CN-110023506-A | The detection method of nucleic acid | 东丽株式会社 | 2019-07-16 | — | — | CN | disclosed |
| CN-109667193-A | A kind of preparation method of composite papermaking retention agent | 常州麒通国际贸易有限公司 | 2019-04-23 | — | — | CN | disclosed |
| CN-109659537-A | Citrate assists Fluorin doped ternary nano piece/polypyrrole preparation method and product and application | 上海纳米技术及应用国家工程研究中心有限公司 | 2019-04-19 | — | — | CN | disclosed |
| WO-2019070924-A1 | DISHWASHING CLEANING COMPOSITION | THE PROCTER & GAMBLE COMPANY (US) | 2019-04-11 | — | — | WO | disclosed |
| US-20190106658-A1 | DISHWASHING CLEANING COMPOSITION | THE PROCTER & GAMBLE COMPANY | 2019-04-11 | — | — | US | disclosed |
| CN-108779455-A | The recovery method of nucleic acid | 东丽株式会社 | 2018-11-09 | — | — | CN | disclosed |
| US-5693602-A | MIXTURE OF AMYLASE AND PROTEASE | COLGATE-PALMOLIVE CO. (US) | 1997-12-02 | — | — | US | disclosed |
| EP-0802969-A1 | DETERGENT COMPOSITION COMPRISING ZEOLITE AND AMYLASE ENZYME | THE PROCTER & GAMBLE COMPANY (US) | 1997-10-29 | — | — | EP | disclosed |
| EP-0802970-A1 | DETERGENT COMPOSITION COMPRISING ZEOLITE MAP AND AMYLASE ENZYMES | THE PROCTER & GAMBLE COMPANY (US) | 1997-10-29 | — | — | EP | disclosed |
| WO-1997017482-A1 | ELECTROPLATING PROCESSES COMPOSITIONS AND DEPOSITS | ENTHONE-OMI INC. (US) | 1997-05-15 | — | — | WO | disclosed |
| WO-1996021718-A1 | DETERGENT COMPOSITION COMPRISING ZEOLITE MAP AND AMYLASE ENZYMES | THE PROCTER & GAMBLE COMPANY (US) | 1996-07-18 | — | — | WO | disclosed |
| WO-1996021717-A1 | DETERGENT COMPOSITION COMPRISING ZEOLITE AND AMYLASE ENZYME | THE PROCTER & GAMBLE COMPANY (US) | 1996-07-18 | — | — | WO | disclosed |
| US-5468411-A | Contains protease and amylase enzymes | COLGATE PALMOLIVE CO. (US) | 1995-11-21 | — | — | US | disclosed |
| US-5173207-A | Protease enzyme and amylase enzyme, nonionic surfactants, alkali metal silicate | COLGATE-PALMOLIVE COMPANY (US) | 1992-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030143259-A1 | For therapy of infections of the eye and surrounding tissues | AZI2, MALT1, PDE6D | MEN1 2597/4885ALDH1A1 1506/4885HMGCR 1371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.