Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.94 |
| ▸ | HMGCR | P04035 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL116215 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL11519286 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL2411531 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL1426398 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL633793 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL7060057 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL11857836 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL8400312 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL4819877 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL3659 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643675-A | MIXTURES OF THERMOSETTING RESIN, LATENT ACID CATALYST AND ALKALI METAL SALT OF POLYBASIC ACID(AS LIFE EXTENDER), FOR MAKING FOUNDRY CORES OR MOLDS WITH SAND | BORDEN, INC. (US) | 1997-07-01 | — | — | US | claimed |
| WO-2022255840-A1 | METHOD FOR ISOLATING EXTRACELLULAR VESICLE USING SALT FRACTIONAL PRECIPITATION | 기초과학연구원 | 2022-12-08 | — | — | WO | disclosed |
| EP-3377044-B1 | IBUPROFEN COMPOSITIONS FOR DIRECT ORAL ADMINISTRATION | HERMES PHARMA GMBH (DE) | 2021-09-29 | — | — | EP | disclosed |
| EP-3377044-A1 | IBUPROFEN COMPOSITIONS FOR DIRECT ORAL ADMINISTRATION | Hermes Arzneimittel GmbH (DE) | 2018-09-26 | — | — | EP | disclosed |
| EP-3107987-A1 | MACHINE DISHWASH COMPOSITION | Unilever N.V. (NL) | 2016-12-28 | — | — | EP | disclosed |
| WO-2015124384-A1 | MACHINE DISHWASH COMPOSITION | UNILEVER N.V. (NL) | 2015-08-27 | — | — | WO | disclosed |
| WO-2015067765-A1 | A BACILLUS SUBTILIS STRAIN DEPOSITED UNDER DEPOSIT NUMBER CECT 8258 AND METHOD FOR PROTECTING OR TREATING PLANTS | SYMBORG S.L. (ES) | 2015-05-14 | — | — | WO | disclosed |
| EP-2563482-A2 | LOTION COMPOSITION FOR WET WIPES | The Procter & Gamble Company (US) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011139492-A2 | LOTION COMPOSITION FOR WET WIPES | THE PROCTER & GAMBLE COMPANY (US) | 2011-11-10 | — | — | WO | disclosed |
| US-20030158375-A1 | G-CSF polypeptides and conjugates | MAXYGEN HOLDINGS, LTD. | 2003-08-21 | — | — | US | disclosed |
| EP-1196530-A1 | DETERGENT COMPOSITIONS COMPRISING A RAW STARCH DEGRADING ENZYME | THE PROCTER & GAMBLE COMPANY (US) | 2002-04-17 | — | — | EP | disclosed |
| EP-1141199-A1 | DETERGENT COMPOSITIONS COMPRISING A PECTATE LYASE AND A SPECIFIC SURFACTANT SYSTEM | THE PROCTER & GAMBLE COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2001002529-A1 | DETERGENT COMPOSITIONS COMPRISING A RAW STARCH DEGRADING ENZYME | THE PROCTER & GAMBLE COMPANY (US) | 2001-01-11 | — | — | WO | disclosed |
| WO-2000042155-A1 | DETERGENT COMPOSITIONS COMPRISING A PECTATE LYASE AND A SPECIFIC SURFACTANT SYSTEM | THE PROCTER & GAMBLE COMPANY (US) | 2000-07-20 | — | — | WO | disclosed |
| US-4820870-A | FOR REMOVAL AND/OR PREVENTION OF URINARY TRACT STONES; SODIUM-POTASSIUM-HYDROGEN SALTS OF CITRIC ACID | DR. MADAUS & CO. (DE) | 1989-04-11 | — | — | US | disclosed |
| US-4400535-A | ADDING AN ALKALI CARBONATE TO A BOILING WATER SOLUTION OF A TRIALKALI CITRATE AND CITRIC ACID; COMPLEXING | DR. MADAUS & CO. (DE) | 1983-08-23 | — | — | US | disclosed |