Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.37 |
| ▸ | PIM1 | P11309 | 5/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.37 |
| ▸ | USP14 | P54578 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | AKT2 | P31751 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1667774 | 1.00 | NTRK1 (0.37) | NTRK1PIM1CHEK1CDK2CSNK2A1 | |
| SCHEMBL12797301 | 0.87 | HSP90AA1 (0.41) | USP14HSP90AA1HSP90AB1FEN1ALDH1A1 | |
| SCHEMBL1077437 | 0.81 | GAA (0.35) | USP14ALDH1A1CYP2C19KDM4EMAPT | |
| SCHEMBL1077441 | 0.81 | GAA (0.35) | USP14ALDH1A1CYP2C19KDM4EMAPT | |
| SCHEMBL1667778 | 0.81 | USP14 (0.36) | USP14FEN1ALDH1A1CYP2C19TSHR | |
| SCHEMBL1667677 | 0.81 | NTRK1 (0.34) | NTRK1PIM1CHEK1CDK2CSNK2A1 | |
| SCHEMBL1667676 | 0.81 | NTRK1 (0.34) | NTRK1PIM1CHEK1CDK2CSNK2A1 | |
| SCHEMBL1667729 | 0.80 | NTRK1 (0.33) | NTRK1PIM1CHEK1CDK2CSNK2A1 | |
| SCHEMBL1667736 | 0.80 | NTRK1 (0.33) | NTRK1PIM1CHEK1CDK2CSNK2A1 | |
| SCHEMBL1667731 | 0.80 | NTRK1 (0.33) | NTRK1PIM1CHEK1CDK2CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011042474-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |